Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0284 | 0.0392 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.1359 | 0.647 | 0.647 |
Brugia malayi | Phospholipase A2 family protein | 0.1359 | 0.647 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0284 | 0.0392 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1359 | 0.647 | 0.647 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.1983 | 1 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0284 | 0.0392 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.068 | 0.2632 | 0.2632 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34 % | Inhibition of human NPP1 using p-Nph-5'-TMP as substrate at 10 uM | ChEMBL. | 25372276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.