Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0277 | 0.2451 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0277 | 0.2451 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.027 | 0.2332 | 0.1528 |
Giardia lamblia | Cathepsin B precursor | 0.035 | 0.3685 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0277 | 0.2451 | 0.6465 |
Echinococcus multilocularis | cathepsin b | 0.0725 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0187 | 0.0949 | 0.0949 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0187 | 0.0949 | 0.0949 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0187 | 0.0949 | 1 |
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Onchocerca volvulus | Cathepsin F homolog | 0.0187 | 0.0949 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Onchocerca volvulus | Cathepsin L homolog | 0.0187 | 0.0949 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Toxoplasma gondii | cathepsin B | 0.035 | 0.3685 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0326 | 0.3281 | 0.2576 |
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Loa Loa (eye worm) | ctsf protein | 0.0187 | 0.0949 | 0.0949 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Loa Loa (eye worm) | cathepsin B | 0.035 | 0.3685 | 0.3685 |
Leishmania major | cathepsin L-like protease | 0.0326 | 0.3281 | 0.8522 |
Giardia lamblia | Cathepsin B precursor | 0.035 | 0.3685 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0187 | 0.0949 | 0.0949 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0187 | 0.0949 | 0.0949 |
Echinococcus granulosus | cathepsin l1 | 0.0187 | 0.0949 | 0.0949 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0187 | 0.0949 | 0.0949 |
Plasmodium vivax | vivapain-2 | 0.0187 | 0.0949 | 0.334 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0187 | 0.0949 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0187 | 0.0949 | 0.0949 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.035 | 0.3685 | 0.3023 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Brugia malayi | Cathepsin L-like precursor | 0.0187 | 0.0949 | 0.0949 |
Brugia malayi | Cathepsin L-like precursor | 0.0187 | 0.0949 | 0.0949 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0277 | 0.2451 | 0.6465 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0326 | 0.3281 | 0.2576 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0277 | 0.2451 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0187 | 0.0949 | 0.334 |
Brugia malayi | Cathepsin L-like precursor | 0.0187 | 0.0949 | 0.0949 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.035 | 0.3685 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0187 | 0.0949 | 0.334 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0326 | 0.3281 | 0.2576 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0277 | 0.2451 | 0.2451 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0187 | 0.0949 | 0.334 |
Loa Loa (eye worm) | fibroinase | 0.0187 | 0.0949 | 0.0949 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Toxoplasma gondii | cathepsin CPC1 | 0.0277 | 0.2451 | 0.6465 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0199 | 0.1147 | 0.0219 |
Echinococcus granulosus | cathepsin b | 0.0725 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0187 | 0.0949 | 0.0949 |
Plasmodium vivax | vivapain-2 | 0.0187 | 0.0949 | 0.334 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0949 | 0.0949 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.035 | 0.3685 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Brugia malayi | Cathepsin L-like precursor | 0.0187 | 0.0949 | 0.0949 |
Toxoplasma gondii | cathepsin CPL | 0.0187 | 0.0949 | 0.216 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.035 | 0.3685 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0725 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0187 | 0.0949 | 1 |
Echinococcus granulosus | cathepsin b | 0.0725 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0725 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0725 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0187 | 0.0949 | 0.2574 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0326 | 0.3281 | 0.2576 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0195 | 0.1072 | 0.2908 |
Onchocerca volvulus | Cathepsin L homolog | 0.0187 | 0.0949 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.035 | 0.3685 | 0.3685 |
Echinococcus multilocularis | cathepsin b | 0.0725 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.035 | 0.3685 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0187 | 0.0949 | 0.0949 |
Leishmania major | cathepsin L-like protease | 0.0326 | 0.3281 | 0.8522 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0277 | 0.2451 | 1 |
Onchocerca volvulus | 0.0187 | 0.0949 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0187 | 0.0949 | 0.0949 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0187 | 0.0949 | 0.0949 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0725 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0326 | 0.3281 | 0.8522 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0725 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.