Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0575 | 0.244 | 0.6743 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0569 | 0.239 | 0.7181 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.2692 | 0.2692 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0764 | 0.4199 | 0.4137 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0764 | 0.4199 | 0.4721 |
Onchocerca volvulus | Matrilysin homolog | 0.065 | 0.3141 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0788 | 0.4429 | 0.5127 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1014 | 0.6529 | 0.669 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.1217 | 0.8421 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0364 | 0.0478 | 0.0303 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0788 | 0.4429 | 0.5009 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0358 | 0.0424 | 0.0237 |
Brugia malayi | hypothetical protein | 0.0358 | 0.0424 | 0.1172 |
Mycobacterium ulcerans | hydrolase | 0.0313 | 0 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.1217 | 0.8421 | 1 |
Echinococcus granulosus | adam 17 protease | 0.1338 | 0.955 | 1 |
Brugia malayi | Matrixin family protein | 0.0701 | 0.3619 | 1 |
Brugia malayi | Hemopexin family protein | 0.0364 | 0.0478 | 0.1321 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0313 | 0 | 0.5 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0602 | 0.2692 | 0.7439 |
Loa Loa (eye worm) | matrixin family protein | 0.0701 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.023 | 0.023 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0788 | 0.4429 | 0.4389 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0313 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1014 | 0.6529 | 0.7635 |
Loa Loa (eye worm) | matrixin family protein | 0.0569 | 0.239 | 0.239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.