Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.2309 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.4278 | 0.1314 | 1 |
Onchocerca volvulus | 0.3151 | 0.0562 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2309 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 1.729 | 1 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.4278 | 0.1314 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.5921 | 0.2411 | 0.2007 |
Schistosoma mansoni | carbonic anhydrase | 0.4278 | 0.1314 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2309 | 0 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.4278 | 0.1314 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2309 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 1.5009 | 0.8477 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2309 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2309 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2309 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2309 | 0 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.3151 | 0.0562 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 1.729 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2309 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.