Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Echinococcus multilocularis | caspase | 0.0733 | 0.9277 | 0.8857 |
Plasmodium falciparum | metacaspase-like protein | 0.037 | 0.3783 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0781 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3783 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0733 | 0.9277 | 0.8837 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.037 | 0.3783 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0781 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.037 | 0.3783 | 0.5 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0733 | 0.9277 | 0.8857 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3783 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.036 | 0.036 |
Trypanosoma cruzi | metacaspase 5, putative | 0.037 | 0.3783 | 0.5 |
Echinococcus multilocularis | caspase 8 | 0.037 | 0.3783 | 0.0178 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.036 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 1 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.037 | 0.3783 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.4394 | 0.4394 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.037 | 0.3783 | 0.5 |
Trypanosoma brucei | Metacaspase-4 | 0.037 | 0.3783 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0411 | 0.4394 | 0.1143 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Trypanosoma brucei | metacaspase MCA2 | 0.037 | 0.3783 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.036 | 0.036 |
Echinococcus granulosus | caspase | 0.0733 | 0.9277 | 0.8857 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3783 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3783 | 0.5 |
Plasmodium vivax | metacaspase 1, putative | 0.037 | 0.3783 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.037 | 0.3783 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.037 | 0.3783 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.037 | 0.3783 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.037 | 0.3783 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0334 | 0.3231 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0411 | 0.4394 | 0.0982 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Plasmodium falciparum | metacaspase 1 | 0.037 | 0.3783 | 0.5 |
Echinococcus granulosus | caspase 8 | 0.037 | 0.3783 | 0.0178 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.037 | 0.3783 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.3783 | 0.3783 |
Trypanosoma brucei | metacaspase 5, putative | 0.037 | 0.3783 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0781 | 1 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0411 | 0.4394 | 0.1143 |
Trypanosoma brucei | metacaspase | 0.037 | 0.3783 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.037 | 0.3783 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0781 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0411 | 0.4394 | 0.4394 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3783 | 0.5 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.037 | 0.3783 | 0.3783 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0733 | 0.9277 | 0.8837 |
Trypanosoma cruzi | metacaspase, putative | 0.037 | 0.3783 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0334 | 0.3231 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3783 | 0.5 |
Leishmania major | metacaspase, putative | 0.037 | 0.3783 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0733 | 0.9277 | 0.8857 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (binding) | = 354.8134 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.