TDR Targets

Basic information

Technical information

TDR Targets ID: 873154
Name: 4-[[3-(phenylmethyl)imidazo[5,4-b]pyridin-2-y l]sulfanylmethyl]-N-(3-propan-2-yloxypropyl)b enzamide
MW: 474.618 | Formula: C27H30N4O2S
H donors: 1 H acceptors: 3 LogP: 4.92 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CC(OCCCNC(=O)c1ccc(cc1)CSc1nc2c(n1Cc1ccccc1)nccc2)C
InChi: 1S/C27H30N4O2S/c1-20(2)33-17-7-16-29-26(32)23-13-11-22(12-14-23)19-34-27-30-24-10-6-15-28-25(24)31(27)18-21-8-4-3-5-9-21/h3-6,8-15,20H,7,16-19H2,1-2H3,(H,29,32)
InChiKey: ASDRPNCDFHEELV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-isopropoxypropyl)-4-[[3-(phenylmethyl)imidazo[5,4-b]pyridin-2-yl]sulfanylmethyl]benzamide
N-(3-isopropoxypropyl)-4-[[[3-(phenylmethyl)-2-imidazo[5,4-b]pyridinyl]thio]methyl]benzamide
4-[[[3-(benzyl)imidazo[5,4-b]pyridin-2-yl]thio]methyl]-N-(3-isopropoxypropyl)benzamide
NCGC00141387-01
E642-0091

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	sex peptide receptor	0.0062	0.121	0.121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Brugia malayi	putative neuropeptide receptor	0.0062	0.121	0.041
Echinococcus granulosus	orexin receptor type 2	0.0062	0.121	0.121
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0069	0.1859	0.1859
Echinococcus multilocularis	sodium and chloride dependent glycine	0.011	0.5341	0.5341
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0062	0.121	0.121
Brugia malayi	neuropeptide F receptor	0.0062	0.121	0.041
Schistosoma mansoni	neuropeptide f receptor 76f	0.0062	0.121	0.0334
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0069	0.1859	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	sex peptide receptor	0.0062	0.121	0.121
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	nmda type glutamate receptor	0.0089	0.3587	0.3587
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Echinococcus multilocularis	neuropeptides capa receptor	0.0062	0.121	0.121
Schistosoma mansoni	glutamate receptor NMDA	0.0148	0.8611	0.8473
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.8314	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0062	0.121	0.0334
Echinococcus multilocularis	neuropeptide receptor	0.0062	0.121	0.121
Echinococcus multilocularis	somatostatin receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	G-protein coupled receptor	0.0062	0.121	0.041
Schistosoma mansoni	amine GPCR	0.0062	0.121	0.0334
Echinococcus multilocularis	orexin receptor type 2	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Brugia malayi	putative neuropeptide receptor NPR1	0.0062	0.121	0.041
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0062	0.121	0.0334
Brugia malayi	Serotonin receptor	0.0062	0.121	0.041
Schistosoma mansoni	neuropeptide receptor	0.0062	0.121	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0062	0.121	0.041
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0062	0.121	0.0334
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus granulosus	g protein coupled receptor	0.0062	0.121	0.121
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0069	0.1859	0.1859
Echinococcus granulosus	neuropeptide FF receptor 2	0.0062	0.121	0.121
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0062	0.121	0.0334
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0062	0.121	0.041
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0062	0.121	0.121
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0069	0.1859	0.1859
Echinococcus multilocularis	allatostatin A receptor	0.0062	0.121	0.121
Brugia malayi	G protein-coupled receptor F59B2.13	0.0062	0.121	0.041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0062	0.121	0.0334
Schistosoma mansoni	growth hormone secretagogue receptor	0.0062	0.121	0.0334
Echinococcus granulosus	g protein coupled receptor	0.0062	0.121	0.121
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Brugia malayi	RE15519p	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	nmda type glutamate receptor	0.01	0.4493	0.4493
Brugia malayi	neuropeptide F receptor	0.0062	0.121	0.041
Echinococcus multilocularis	serotonin receptor	0.0062	0.121	0.121
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Schistosoma mansoni	neuropeptide receptor	0.0062	0.121	0.0334
Schistosoma mansoni	opsin-like receptor	0.0062	0.121	0.0334
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0069	0.1859	0.1859
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	tm gpcr rhodopsin	0.0062	0.121	0.121
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0062	0.121	0.0334
Onchocerca volvulus		0.0062	0.121	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.8314	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	neuropeptide receptor	0.0062	0.121	0.121
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0062	0.121	0.041
Echinococcus granulosus	neuropeptide s receptor	0.0062	0.121	0.121
Onchocerca volvulus		0.0062	0.121	0.5
Brugia malayi	G-protein coupled receptor	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0062	0.121	0.121
Brugia malayi	G-protein coupled receptor	0.0062	0.121	0.041
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0062	0.121	0.121
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0062	0.121	0.0334
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0062	0.121	0.041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Schistosoma mansoni	myosin xvIII	0.0062	0.121	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Brugia malayi	Melatonin receptor type 1A	0.0062	0.121	0.041
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	biogenic amine receptor	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	neuropeptides capa receptor	0.0062	0.121	0.121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Schistosoma mansoni	opsin-like receptor	0.0062	0.121	0.0334
Echinococcus granulosus	sodium and chloride dependent glycine	0.011	0.5341	0.5341
Echinococcus multilocularis	g protein coupled receptor	0.0062	0.121	0.121
Echinococcus granulosus	biogenic amine 5HT receptor	0.0062	0.121	0.121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Onchocerca volvulus		0.0062	0.121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	biogenic amine receptor	0.0062	0.121	0.0334
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0069	0.1859	0.1859
Brugia malayi	larval opioid receptor	0.0062	0.121	0.041
Schistosoma mansoni	amine GPCR	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0062	0.121	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0069	0.1859	0.1859
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0062	0.121	0.121
Echinococcus multilocularis	neuropeptide receptor A26	0.0062	0.121	0.121
Echinococcus granulosus	sodium and chloride dependent glycine	0.011	0.5341	0.5341
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0062	0.121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0062	0.121	0.5
Brugia malayi	AKH receptor	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	g protein coupled receptor	0.0062	0.121	0.121
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0062	0.121	0.121
Loa Loa (eye worm)	G-protein coupled receptor	0.0062	0.121	0.041
Schistosoma mansoni	glutamate receptor NMDA	0.0164	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0062	0.121	0.041
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0164	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0062	0.121	0.0334
Schistosoma mansoni	neuropeptide receptor	0.0062	0.121	0.0334
Echinococcus granulosus	g-protein coupled receptor	0.0062	0.121	0.121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0062	0.121	0.121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Echinococcus granulosus	g protein coupled receptor	0.0062	0.121	0.121
Echinococcus granulosus	neuropeptide receptor A26	0.0062	0.121	0.121
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0062	0.121	0.0334
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0062	0.121	0.121
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	G protein coupled receptor 139	0.0062	0.121	0.121
Echinococcus multilocularis	g protein coupled receptor	0.0062	0.121	0.121
Echinococcus multilocularis	nmda type glutamate receptor	0.0089	0.3587	0.3587
Echinococcus multilocularis	serotonin receptor	0.0062	0.121	0.121
Echinococcus multilocularis	glutamate receptor 2	0.0069	0.1859	0.1859
Brugia malayi	sulfakinin receptor protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	allatostatin A receptor	0.0062	0.121	0.121
Echinococcus granulosus	serotonin receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0062	0.121	0.121
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0062	0.121	0.041
Echinococcus multilocularis	neuropeptide Y receptor	0.0062	0.121	0.121
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0062	0.121	0.121
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Echinococcus granulosus	glutamate receptor 2	0.0069	0.1859	0.1859
Schistosoma mansoni	biogenic amine receptor	0.0062	0.121	0.0334
Schistosoma mansoni	amine GPCR	0.0062	0.121	0.0334
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Loa Loa (eye worm)	neuropeptide F receptor	0.0062	0.121	0.041
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0062	0.121	0.0334
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0062	0.121	0.041
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	neuropeptide Y receptor	0.0062	0.121	0.121
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	neuropeptide receptor	0.0062	0.121	0.121
Brugia malayi	GnHR receptor homolog	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	g-protein coupled receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	TYRA-2 protein	0.0062	0.121	0.041
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0062	0.121	0.0334
Schistosoma mansoni	neuropeptide F-like receptor	0.0062	0.121	0.0334
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0062	0.121	0.121
Echinococcus granulosus	rhodopsin orphan GPCR	0.0062	0.121	0.121
Echinococcus granulosus	biogenic amine 5HT receptor	0.0062	0.121	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Brugia malayi	ORL1-like opioid receptor	0.0062	0.121	0.041
Schistosoma mansoni	hypothetical protein	0.0062	0.121	0.0334
Schistosoma mansoni	histamine h1 receptor	0.0062	0.121	0.0334
Echinococcus multilocularis	fmrfamide receptor	0.0062	0.121	0.121
Echinococcus multilocularis	fmrfamide receptor	0.0062	0.121	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.011	0.5341	0.5987
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	neuropeptide F receptor	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0062	0.121	0.0334
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0062	0.121	0.121
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.011	0.5341	0.5987
Echinococcus multilocularis	neuropeptides capa receptor	0.0062	0.121	0.121
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0062	0.121	0.121
Echinococcus multilocularis	glutamate receptor NMDA	0.0078	0.2634	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	hypothetical protein	0.0062	0.121	0.121
Echinococcus multilocularis	neuropeptide s receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	somatostatin receptor	0.0062	0.121	0.121
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0062	0.121	0.121
Brugia malayi	follicle stimulating hormone receptor	0.0062	0.121	0.041
Schistosoma mansoni	amine GPCR	0.0062	0.121	0.0334
Echinococcus granulosus	dro:myosuppressin receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.011	0.5341	0.5987
Schistosoma mansoni	neuropeptide F-like receptor	0.0062	0.121	0.0334
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0062	0.121	0.121
Schistosoma mansoni	sodium/chloride dependent transporter	0.011	0.5341	0.4876
Echinococcus multilocularis	neuropeptide receptor	0.0062	0.121	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	neuropeptide Y receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	amine GPCR	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0062	0.121	0.0334
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0062	0.121	0.121
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0062	0.121	0.121
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	tm gpcr rhodopsin	0.0062	0.121	0.121
Brugia malayi	G protein-coupled receptor	0.0062	0.121	0.041
Echinococcus multilocularis	nmda type glutamate receptor	0.01	0.4493	0.4493
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0062	0.121	0.041
Brugia malayi	MH2 domain containing protein	0.0144	0.8314	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0069	0.1859	0.1859
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0062	0.121	0.121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Brugia malayi	Dopamine receptor protein 2	0.0062	0.121	0.041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0062	0.121	0.121
Echinococcus multilocularis	sodium and chloride dependent glycine	0.011	0.5341	0.5341
Brugia malayi	Serotonin receptor	0.0062	0.121	0.041
Schistosoma mansoni	hypothetical protein	0.0062	0.121	0.0334
Brugia malayi	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus granulosus	glutamate receptor NMDA	0.0078	0.2634	0.2634
Schistosoma mansoni	adenoreceptor	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	hypothetical protein	0.0062	0.121	0.0334
Echinococcus granulosus	7tm_1 domain containing protein	0.0062	0.121	0.121
Echinococcus multilocularis	dro:myosuppressin receptor	0.0062	0.121	0.121
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus granulosus	fmrfamide receptor	0.0062	0.121	0.121
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0062	0.121	0.0334
Echinococcus granulosus	neuropeptide Y receptor	0.0062	0.121	0.121
Echinococcus granulosus	tm gpcr rhodopsin	0.0062	0.121	0.121
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0062	0.121	0.121
Loa Loa (eye worm)	melatonin receptor type 1A	0.0062	0.121	0.041
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0062	0.121	0.0334
Schistosoma mansoni	sodium/chloride dependent transporter	0.011	0.5341	0.4876
Brugia malayi	Dopamine receptor	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0062	0.121	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0062	0.121	0.0334
Echinococcus multilocularis	glutamate receptor 2	0.0058	0.0906	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	hypothetical protein	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0062	0.121	0.121
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0062	0.121	0.121
Schistosoma mansoni	neuropeptide receptor	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Onchocerca volvulus		0.0062	0.121	0.5
Brugia malayi	Dopamine receptor protein 1	0.0062	0.121	0.041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0062	0.121	0.041
Schistosoma mansoni	opsin-like receptor	0.0062	0.121	0.0334
Loa Loa (eye worm)	hypothetical protein	0.011	0.5341	0.5987

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1866066
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 873154