Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0967 | 0.314 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0967 | 0.314 | 0.5259 |
Onchocerca volvulus | Papilin homolog | 0.0731 | 0.1938 | 0.8363 |
Brugia malayi | Hemopexin family protein | 0.0456 | 0.0539 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.2314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 0.0211 | 0.0211 |
Schistosoma mansoni | hypothetical protein | 0.0456 | 0.0539 | 0.109 |
Loa Loa (eye worm) | matrixin family protein | 0.0849 | 0.254 | 0.254 |
Brugia malayi | ADAMTS-like protease | 0.071 | 0.1833 | 0.1656 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.124 | 0.4532 | 1 |
Brugia malayi | hypothetical protein | 0.0663 | 0.1596 | 0.1415 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0391 | 0.0211 | 0.5 |
Brugia malayi | angiogenesis inhibito | 0.071 | 0.1833 | 0.1656 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0967 | 0.314 | 0.5259 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0663 | 0.1596 | 0.4713 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0713 | 0.1847 | 0.7818 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.036 | 0.0052 | 0.0052 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0391 | 0.0211 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0731 | 0.1938 | 0.1938 |
Brugia malayi | Matrixin family protein | 0.0849 | 0.254 | 0.2378 |
Mycobacterium ulcerans | hydrolase | 0.0391 | 0.0211 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0663 | 0.1596 | 0.1596 |
Onchocerca volvulus | Matrilysin homolog | 0.0784 | 0.2212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.022 | 0.022 |
Loa Loa (eye worm) | matrixin family protein | 0.0713 | 0.1847 | 0.1847 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.124 | 0.4532 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1042 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.