Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.0113 | 0.0148 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.0113 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0265 | 0.2058 | 1 |
Schistosoma mansoni | single-minded | 0.0054 | 0.0127 | 0.0011 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0265 | 0.2058 | 1 |
Leishmania major | trypanothione reductase | 0.0052 | 0.0113 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0265 | 0.2058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.4098 | 0.5274 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0054 | 0.0127 | 0.0011 |
Brugia malayi | Pre-SET motif family protein | 0.0265 | 0.2058 | 0.2684 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.012 | 0.0582 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0265 | 0.2058 | 0.3029 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1278 | 0.1542 |
Brugia malayi | PAS domain containing protein | 0.0054 | 0.0127 | 0.0166 |
Brugia malayi | glutathione reductase | 0.0052 | 0.0113 | 0.0148 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0879 | 0.7669 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.012 | 0.0582 |
Brugia malayi | hypoxia-induced factor 1 | 0.0166 | 0.1151 | 0.1501 |
Brugia malayi | hypothetical protein | 0.018 | 0.1278 | 0.1667 |
Trichomonas vaginalis | set domain proteins, putative | 0.1134 | 1 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.0113 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0265 | 0.2058 | 0.3029 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0166 | 0.1151 | 0.1374 |
Mycobacterium ulcerans | putative regulatory protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0255 | 0.1969 | 0.9567 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.0113 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0753 | 0.6518 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0265 | 0.2058 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.0113 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0265 | 0.2058 | 0.3029 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2058 | 0.2574 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0265 | 0.2058 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0879 | 0.7669 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.3937 | 0.506 |
Brugia malayi | SET domain containing protein | 0.0498 | 0.4187 | 0.546 |
Onchocerca volvulus | 0.0753 | 0.6518 | 0.6518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.