Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.7147 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1938 | 0.1938 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.0059 | 0.0052 | 0.0052 |
Brugia malayi | ADAMTS-like protease | 0.0116 | 0.1833 | 0.0281 |
Brugia malayi | angiogenesis inhibito | 0.0116 | 0.1833 | 0.0281 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.6064 | 0.5316 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0158 | 0.314 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0158 | 0.314 | 1 |
Onchocerca volvulus | 0.0286 | 0.7147 | 1 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.6064 | 0.6064 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0158 | 0.314 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.