TDR Targets

Basic information

Technical information

TDR Targets ID: 875403
Name: N'-(3-chloro-4-methylphenyl)-N-[2-(4-phenylpi perazin-1-yl)-2-pyridin-3-ylethyl]oxamide
MW: 477.986 | Formula: C26H28ClN5O2
H donors: 2 H acceptors: 3 LogP: 3.89 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(=O)NCC(c1cccnc1)N1CCN(CC1)c1ccccc1)Nc1ccc(c(c1)Cl)C
InChi: 1S/C26H28ClN5O2/c1-19-9-10-21(16-23(19)27)30-26(34)25(33)29-18-24(20-6-5-11-28-17-20)32-14-12-31(13-15-32)22-7-3-2-4-8-22/h2-11,16-17,24H,12-15,18H2,1H3,(H,29,33)(H,30,34)
InChiKey: LKAQIYQPNYFQHM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(3-chloro-4-methyl-phenyl)-N-[2-(4-phenylpiperazin-1-yl)-2-(3-pyridyl)ethyl]oxamide
N'-(3-chloro-4-methylphenyl)-N-[2-(4-phenyl-1-piperazinyl)-2-(3-pyridyl)ethyl]oxamide
N'-(3-chloro-4-methyl-phenyl)-N-[2-(4-phenylpiperazin-1-yl)-2-pyridin-3-yl-ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	serine:threonine protein kinase N2	0.005	0.0562	0.0875
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0562	0.0813
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.1215	0.2891
Brugia malayi	diacylglycerol kinase	0.0035	0.0307	0.0307
Echinococcus multilocularis	serine threonine protein kinase	0.0052	0.0599	0.1
Entamoeba histolytica	protein kinase, putative	0.005	0.0562	0.1807
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Brugia malayi	Hr1 repeat family protein	0.005	0.0562	0.0562
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.005	0.0562	0.0875
Brugia malayi	Protein kinase c protein 2	0.0039	0.0362	0.0362
Echinococcus multilocularis	protein kinase c epsilon type	0.0203	0.3226	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.005	0.0562	0.5
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0037	0.0326	0.0023
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0037	0.0326	0.0326
Brugia malayi	Ras association domain family 1 isoform A	0.0035	0.0307	0.0307
Brugia malayi	C1-like domain containing protein	0.0037	0.0326	0.0326
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0326	0.0326
Echinococcus granulosus	serine:threonine protein kinase N2	0.0117	0.172	0.4841
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0086	0.118	0.299
Onchocerca volvulus		0.0038	0.0343	0.0049
Echinococcus granulosus	Protein kinase C brain isozyme	0.0088	0.1215	0.3112
Brugia malayi	Protein kinase domain containing protein	0.005	0.0562	0.0562
Echinococcus multilocularis	serine:threonine protein kinase 38	0.005	0.0562	0.0875
Echinococcus multilocularis	protein kinase c iota type	0.0086	0.1179	0.2987
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0562	0.0813
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0086	0.118	0.299
Schistosoma mansoni	jun-related protein	0.0146	0.2222	0.6094
Loa Loa (eye worm)	hypothetical protein	0.0174	0.2721	0.2908
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0562	0.0562
Loa Loa (eye worm)	AGC/AKT protein kinase	0.005	0.0562	0.0308
Brugia malayi	RhoGEF domain containing protein	0.0035	0.0307	0.0307
Brugia malayi	p70 ribosomal S6 kinase beta	0.005	0.0562	0.0562
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0037	0.0326	0.0064
Onchocerca volvulus		0.0141	0.2137	0.2464
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Schistosoma mansoni	protein kinase C mu	0.0037	0.0326	0.006
Brugia malayi	bZIP transcription factor family protein	0.0179	0.2806	0.2806
Onchocerca volvulus		0.0463	0.7734	1
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0326	0.006
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0166	0.2573	0.7763
Entamoeba histolytica	protein kinase, putative	0.005	0.0562	0.1807
Echinococcus granulosus	protein kinase c iota type	0.0086	0.1179	0.2987
Brugia malayi	Pleckstrin Homology Domain	0.0035	0.0307	0.0307
Entamoeba histolytica	protein kinase, putative	0.005	0.0562	0.1807
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0037	0.0326	0.0064
Echinococcus granulosus	protein kinase C gamma type	0.0052	0.0599	0.1
Brugia malayi	RhoGAP domain containing protein	0.0035	0.0307	0.0307
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0038	0.0343	0.0125
Echinococcus granulosus	unc 13 munc13	0.0038	0.0343	0.0125
Echinococcus multilocularis	unc 13 (munc13)	0.0038	0.0343	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0513	0.8606	1
Echinococcus granulosus	jun protein	0.0179	0.2806	0.856
Toxoplasma gondii	AGC kinase	0.005	0.0562	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.005	0.0562	0.0308
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0203	0.3226	0.3518
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0117	0.172	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7734	0.8949
Brugia malayi	protein kinase C II.	0.0203	0.3226	0.3226
Brugia malayi	hypothetical protein	0.0141	0.2137	0.2137
Schistosoma mansoni	serine/threonine kinase	0.005	0.0562	0.0813
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0088	0.1215	0.3112
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0307	0.0307
Entamoeba histolytica	protein kinase, putative	0.005	0.0562	0.1807
Echinococcus granulosus	NDR protein kinase	0.005	0.0562	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7734	0.8949
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0179	0.2806	0.856
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Brugia malayi	Protein kinase domain containing protein	0.005	0.0562	0.0562
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0562	0.0813
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.005	0.0562	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0251	0.4055	0.4516
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0326	0.006
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.005	0.0562	0.0875
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.005	0.0562	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0125	0.187	0.1883
Schistosoma mansoni	unc-13 (munc13)	0.0038	0.0343	0.0116
Schistosoma mansoni	atypical protein kinase C	0.0086	0.1179	0.2774
Brugia malayi	protein kinase C3,putative	0.0037	0.0326	0.0326
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.005	0.0562	0.0308
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0037	0.0326	0.0023
Loa Loa (eye worm)	AGC/PKN protein kinase	0.005	0.0562	0.0308
Schistosoma mansoni	unc-13 (munc13)	0.0038	0.0343	0.0116
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.3226	0.9289
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.1215	0.2891
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.005	0.0562	0.0875
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.005	0.0562	0.0875
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.005	0.0562	0.0875
Brugia malayi	RhoGAP domain containing protein	0.0035	0.0307	0.0307
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.005	0.0562	0.0308
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.005	0.0562	0.0308
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Echinococcus granulosus	protein kinase c epsilon type	0.0203	0.3226	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0343	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0467	0.7814	0.9046
Trichomonas vaginalis	AGC family protein kinase	0.005	0.0562	1
Loa Loa (eye worm)	hypothetical protein	0.0498	0.8351	0.9692
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0216	0.345	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.005	0.0562	0.0875
Schistosoma mansoni	hypothetical protein	0.0146	0.2222	0.6094
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0038	0.0343	0.0125
Schistosoma mansoni	protein kinase C	0.0038	0.0343	0.0116
Echinococcus multilocularis	jun protein	0.0179	0.2806	0.856
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0562	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7734	0.8949
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0179	0.2806	0.856
Brugia malayi	diacylglycerol kinase	0.0035	0.0307	0.0307

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 875403