Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0445 | 0.0445 |
Brugia malayi | Fibronectin type III domain containing protein | 0.009 | 0.0096 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0445 | 0.5187 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.009 | 0.0096 | 0.0096 |
Onchocerca volvulus | 0.0146 | 0.0657 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0445 | 0.0445 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0091 | 0.0111 | 0.0111 |
Echinococcus multilocularis | roundabout 2 | 0.009 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | TK protein kinase | 0.1077 | 1 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0091 | 0.0111 | 0.023 |
Echinococcus multilocularis | tyrosine protein kinase | 0.1077 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0092 | 0.0118 | 0.0118 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0091 | 0.0111 | 0.0111 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0157 | 0.0769 | 1 |
Echinococcus granulosus | roundabout 2 | 0.009 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0445 | 0.0445 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0157 | 0.0769 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.1062 | 0.9856 | 0.9856 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0096 | 0.0096 |
Echinococcus granulosus | MAM | 0.0124 | 0.0445 | 0.0445 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0096 | 0.0096 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0157 | 0.0769 | 0.0769 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0157 | 0.0769 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0769 | 0.0769 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0157 | 0.0769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1053 | 0.9766 | 0.9766 |
Brugia malayi | Protein kinase domain containing protein | 0.1063 | 0.986 | 0.986 |
Echinococcus granulosus | tyrosine protein kinase | 0.1077 | 1 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0157 | 0.0769 | 0.0769 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0091 | 0.0111 | 0.0111 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0157 | 0.0769 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0091 | 0.0111 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0445 | 0.5187 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0157 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.8373 | 0.8373 |
Brugia malayi | hypothetical protein | 0.0124 | 0.0445 | 0.0445 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0092 | 0.0118 | 0.0118 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0157 | 0.0769 | 0.5 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0157 | 0.0769 | 0.0769 |
Brugia malayi | hypothetical protein | 0.009 | 0.0096 | 0.0096 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0157 | 0.0769 | 1 |
Echinococcus multilocularis | MAM | 0.0124 | 0.0445 | 0.0445 |
Toxoplasma gondii | hypothetical protein | 0.0116 | 0.0361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0096 | 0.0096 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0157 | 0.0769 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.