Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.6833 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0418 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2496 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.2496 | 0.3647 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0169 | 0.6844 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0418 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | 0.024 | 1 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.2496 | 0.3653 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2496 | 0.3653 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2496 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.6833 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0021 | 0.0021 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2496 | 0.5 |
Echinococcus granulosus | jun protein | 0.0169 | 0.6844 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0169 | 0.6844 | 0.6844 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0169 | 0.6844 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.024 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0138 | 0.543 | 0.7947 |
Brugia malayi | hypothetical protein | 0.0133 | 0.5223 | 0.5223 |
Echinococcus multilocularis | geminin | 0.0169 | 0.6833 | 0.9984 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0418 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.4606 | 0.4606 |
Brugia malayi | hypothetical protein | 0.0072 | 0.2496 | 0.2496 |
Echinococcus granulosus | geminin | 0.0169 | 0.6833 | 0.9984 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.4606 | 0.4606 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0418 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.543 | 0.7947 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.2496 | 0.3647 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.6637 | 0.6637 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0418 | 0.0418 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.2496 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0418 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0418 | 0.0418 |
Echinococcus multilocularis | jun protein | 0.0169 | 0.6844 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.4606 | 0.4606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.