Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.1036 | 0.8804 | 0.8804 |
Entamoeba histolytica | hypothetical protein | 0.0195 | 0.0327 | 0.5 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0554 | 0.395 | 0.395 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0554 | 0.395 | 0.395 |
Brugia malayi | Protein kinase domain containing protein | 0.0195 | 0.0327 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0162 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0195 | 0.0327 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0195 | 0.0327 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0195 | 0.0327 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0195 | 0.0327 | 0.5 |
Onchocerca volvulus | 0.0162 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.0195 | 0.0327 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0554 | 0.395 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0162 | 0 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0554 | 0.395 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0162 | 0 | 0.5 |
Onchocerca volvulus | 0.0162 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0307 | 0.9383 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.1155 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0162 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0162 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0307 | 0.9383 |
Echinococcus granulosus | dual specificity | 0.0195 | 0.0327 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0195 | 0.0327 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0162 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0162 | 0 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0195 | 0.0327 | 1 |
Onchocerca volvulus | 0.0162 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0195 | 0.0327 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0195 | 0.0327 | 0.0827 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0162 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0195 | 0.0327 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.