Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3083 | 1 | 0.5 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus multilocularis | protein dispatched 1 | 0.1269 | 0.4085 | 0.4085 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1446 | 0.4663 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3083 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1446 | 0.4663 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1269 | 0.4085 | 0.4085 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.1269 | 0.4085 | 0.4085 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1269 | 0.4085 | 0.4085 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3083 | 1 | 0.5 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3083 | 1 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3083 | 1 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3083 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1269 | 0.4085 | 0.4085 |
Brugia malayi | CHE-14 protein | 0.1269 | 0.4085 | 0.4085 |
Echinococcus multilocularis | protein patched | 0.1269 | 0.4085 | 0.4085 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1269 | 0.4085 | 0.4085 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1269 | 0.4085 | 0.4085 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1269 | 0.4085 | 0.4085 |
Loa Loa (eye worm) | hypothetical protein | 0.1269 | 0.4085 | 0.4085 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1446 | 0.4663 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.3083 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3083 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.1269 | 0.4085 | 0.4085 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1446 | 0.4663 | 0.5 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0 | 0.5 | |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3083 | 1 | 1 |
Onchocerca volvulus | 0.0016 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.