TDR Targets

Basic information

Technical information

TDR Targets ID: 877670
Name: N-[(3,5-difluorophenyl)methyl]-4-methylbenzen esulfonamide
MW: 297.32 | Formula: C14H13F2NO2S
H donors: 1 H acceptors: 2 LogP: 2.95 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)NCc1cc(F)cc(c1)F
InChi: 1S/C14H13F2NO2S/c1-10-2-4-14(5-3-10)20(18,19)17-9-11-6-12(15)8-13(16)7-11/h2-8,17H,9H2,1H3
InChiKey: HZUUCJIMBHUHLR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[(3,5-difluorophenyl)methyl]-4-methyl-benzenesulfonamide
N-(3,5-difluorobenzyl)-4-methyl-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	histone deacetylase 3	0.0074	0.3638	0.3121
Leishmania major	histone deacetylase, putative	0.0074	0.3638	1
Brugia malayi	RNA binding protein	0.0064	0.3007	0.4012
Plasmodium falciparum	histone deacetylase 2	0.0057	0.2539	0.6978
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0395	0.0572
Brugia malayi	TAR-binding protein	0.0064	0.3007	0.4012
Trypanosoma cruzi	histone deacetylase, putative	0.0057	0.2539	0.619
Trypanosoma cruzi	histone deacetylase 1, putative	0.0074	0.3638	1
Entamoeba histolytica	histone deacetylase, putative	0.0074	0.3638	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0395	1
Echinococcus granulosus	histone deacetylase 6	0.0063	0.293	0.2355
Toxoplasma gondii	histone deacetylase HDAC1	0.0057	0.2539	0.619
Trypanosoma cruzi	histone deacetylase, putative	0.0057	0.2539	0.619
Echinococcus granulosus	histone deacetylase 6	0.0057	0.2539	0.1932
Trypanosoma brucei	histone deacetylase 3	0.0057	0.2539	0.619
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0074	0.3638	0.5
Echinococcus granulosus	histone deacetylase 6	0.0057	0.2539	0.1932
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3007	0.2438
Trichomonas vaginalis	histone deacetylase, putative	0.0074	0.3638	0.5
Echinococcus multilocularis	histone deacetylase 6	0.0063	0.293	0.2355
Echinococcus granulosus	histone deacetylase 7	0.0057	0.2539	0.1932
Brugia malayi	Histone deacetylase 1	0.0074	0.3638	0.4981
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0395	0.5
Schistosoma mansoni	histone deacetylase 4 5	0.0057	0.2539	0.1932
Trypanosoma brucei	histone deacetylase, putative	0.0057	0.2539	0.619
Schistosoma mansoni	histone deacetylase hda2	0.0063	0.293	0.2355
Brugia malayi	hypothetical protein	0.0124	0.6907	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0395	1
Schistosoma mansoni	hypothetical protein	0.0172	1	1
Echinococcus multilocularis	histone deacetylase	0.0057	0.2539	0.1932
Trichomonas vaginalis	histone deacetylase, putative	0.0074	0.3638	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0395	1
Trypanosoma brucei	histone deacetylase 4	0.0057	0.2539	0.619
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.6907	1
Trypanosoma cruzi	histone deacetylase, putative	0.0057	0.2539	0.619
Brugia malayi	histone deacetylase 1 (HD1)	0.0074	0.3638	0.4981
Loa Loa (eye worm)	hypothetical protein	0.0034	0.101	0.1463
Brugia malayi	histone deacetylase 3 (HD3)	0.0074	0.3638	0.4981
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0395	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0395	1
Leishmania major	histone deacetylase, putative	0.0057	0.2539	0.661
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0074	0.3638	0.5
Schistosoma mansoni	histone deacetylase	0.0074	0.3638	0.3121
Brugia malayi	histone deacetylase 11	0.003	0.0752	0.0549
Trichomonas vaginalis	histone deacetylase, putative	0.0074	0.3638	0.5
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0395	1
Loa Loa (eye worm)	histone deacetylase	0.0057	0.2539	0.3676
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0395	1
Leishmania major	histone deacetylase, putative	0.0057	0.2539	0.661
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.3007	0.2438
Loa Loa (eye worm)	RNA binding protein	0.0064	0.3007	0.4354
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3007	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0619	0.0896
Trichomonas vaginalis	histone deacetylase, putative	0.0074	0.3638	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.3007	0.4354
Plasmodium vivax	histone deacetylase 1, putative	0.0074	0.3638	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.3007	0.4354
Echinococcus multilocularis	histone deacetylase 7	0.0057	0.2539	0.1932
Toxoplasma gondii	histone deacetylase HDAC2	0.0074	0.3638	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0074	0.3638	0.5
Echinococcus multilocularis	geminin	0.0172	1	1
Giardia lamblia	Histone deacetylase	0.0074	0.3638	0.5
Echinococcus granulosus	histone deacetylase 1	0.0074	0.3638	0.3121
Plasmodium vivax	histone deacetylase 2, putative	0.0057	0.2539	0.6978
Brugia malayi	Histone deacetylase family protein	0.0057	0.2539	0.3292
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0395	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.6907	1
Schistosoma mansoni	histone deacetylase	0.0074	0.3638	0.3121
Echinococcus granulosus	tar DNA binding protein	0.0064	0.3007	0.2438
Echinococcus multilocularis	histone deacetylase 6	0.0057	0.2539	0.1932
Plasmodium falciparum	histone deacetylase, putative	0.0057	0.2539	0.6978
Trichomonas vaginalis	histone deacetylase, putative	0.0074	0.3638	0.5
Loa Loa (eye worm)	histone deacetylase 11	0.003	0.0752	0.1089
Echinococcus multilocularis	histone deacetylase 1	0.0074	0.3638	0.3121
Loa Loa (eye worm)	histone deacetylase 7A	0.0057	0.2539	0.3676
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0	0.5
Loa Loa (eye worm)	histone deacetylase 3	0.0074	0.3638	0.5268
Echinococcus granulosus	histone deacetylase	0.0057	0.2539	0.1932
Trypanosoma cruzi	histone deacetylase 1, putative	0.0074	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0395	0.0572
Schistosoma mansoni	histone deacetylase 4 5	0.0057	0.2539	0.1932
Echinococcus multilocularis	histone deacetylase 3	0.0074	0.3638	0.3121
Onchocerca volvulus	Huntingtin homolog	0.0124	0.6907	1
Brugia malayi	Histone deacetylase family protein	0.0057	0.2539	0.3292
Trichomonas vaginalis	histone deacetylase, putative	0.0074	0.3638	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0395	1
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.3007	0.4012
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3007	0.2438
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3007	0.2438
Loa Loa (eye worm)	hypothetical protein	0.0074	0.3638	0.5268
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.3007	0.2438
Trypanosoma brucei	histone deacetylase 1	0.0074	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0395	0.0572
Plasmodium vivax	histone deacetylase, putative	0.003	0.0752	0.2068
Onchocerca volvulus	Histone deacetylase 10 homolog	0.003	0.0752	0.0549
Loa Loa (eye worm)	hypothetical protein	0.003	0.0752	0.1089
Leishmania major	histone deacetylase, putative	0.0074	0.3638	1
Onchocerca volvulus	Huntingtin homolog	0.0124	0.6907	1
Plasmodium falciparum	histone deacetylase 1	0.0074	0.3638	1
Echinococcus multilocularis	histone deacetylase 6	0.0057	0.2539	0.1932
Schistosoma mansoni	hypothetical protein	0.0172	1	1
Toxoplasma gondii	histone deacetylase HDAC3	0.0074	0.3638	1
Plasmodium vivax	histone deacetylase, putative	0.0057	0.2539	0.6978
Loa Loa (eye worm)	histone deacetylase 1	0.0074	0.3638	0.5268

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 877670