Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0111 | 0.5651 | 0.6146 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.6261 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.0985 | 0.5 |
Brugia malayi | glutathione reductase | 0.0052 | 0.0985 | 0.1071 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.0985 | 0.5 |
Brugia malayi | Lipase family protein | 0.0156 | 0.9194 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.6261 | 0.8342 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.0985 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | amidase | 0.0111 | 0.5651 | 0.6146 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.6261 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.6261 | 0.8342 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0156 | 0.9194 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0111 | 0.5651 | 0.5651 |
Loa Loa (eye worm) | lipase | 0.0156 | 0.9194 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0156 | 0.9194 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0132 | 0.7309 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.6261 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.0985 | 0.1071 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0156 | 0.9194 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0111 | 0.5651 | 0.6146 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.6261 | 0.8342 |
Trypanosoma brucei | lipase domain protein, putative | 0.0156 | 0.9194 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0132 | 0.7309 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.0985 | 0.1071 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0156 | 0.9194 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0156 | 0.9194 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.0985 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0111 | 0.5651 | 0.6146 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0156 | 0.9194 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0132 | 0.7309 | 1 |
Schistosoma mansoni | amidase | 0.0111 | 0.5651 | 0.5651 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5651 | 0.5684 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0111 | 0.5651 | 0.6146 |
Trypanosoma brucei | lipase domain protein, putative | 0.0156 | 0.9194 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.0985 | 0.1071 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.7309 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.0985 | 0.5 |
Onchocerca volvulus | 0.0156 | 0.9194 | 0.5 | |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0156 | 0.9194 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.