Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | ribokinase, putative | 0.0032 | 0 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0264 | 0.2884 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.0032 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0062 | 0.0379 | 0.0379 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0264 | 0.2884 | 1 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | ribokinase | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | 0.0835 | 1 | 1 | |
Trichomonas vaginalis | ribokinase, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | ribokinase | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | adenosine kinase | 0.0032 | 0 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0264 | 0.2884 | 1 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0032 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0264 | 0.2884 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0264 | 0.2884 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0264 | 0.2884 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0101 | 0.0854 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0101 | 0.0854 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0264 | 0.2884 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0101 | 0.0854 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0032 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0264 | 0.2884 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.0032 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0101 | 0.0854 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0101 | 0.0854 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0101 | 0.0854 | 1 |
Echinococcus granulosus | ribokinase | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | kinase, PfkB family | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0062 | 0.0379 | 0.0379 |
Schistosoma mansoni | adenosine kinase | 0.0032 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0264 | 0.2884 | 0.5 |
Giardia lamblia | Ribokinase | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0101 | 0.0854 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.