TDR Targets

Basic information

Technical information

TDR Targets ID: 878805
Name: 5-[(3-bromophenyl)amino]-6-methyl-2H-1,2,4-tr iazin-3-one
MW: 281.109 | Formula: C10H9BrN4O
H donors: 2 H acceptors: 4 LogP: 2.14 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cccc(c1)Nc1nc(O)nnc1C
InChi: 1S/C10H9BrN4O/c1-6-9(13-10(16)15-14-6)12-8-4-2-3-7(11)5-8/h2-5H,1H3,(H2,12,13,15,16)
InChiKey: BLWZPFOTCKDVPC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC00150594
ST5205112

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.0695	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.008	0.0364	0.0364
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0056	0.0106	0.0106
Giardia lamblia	Kinase, PLK	0.0111	0.0695	0.0596
Trichomonas vaginalis	CMGC family protein kinase	0.0984	1	1
Brugia malayi	serine/threonine protein kinase 6	0.007	0.0258	0.0154
Trichomonas vaginalis	CMGC family protein kinase	0.0984	1	1
Entamoeba histolytica	cyclin, putative	0.008	0.0364	0.4391
Echinococcus granulosus	CDC7 cell division cycle 7	0.0984	1	1
Leishmania major	cyclin	0.008	0.0364	0.4391
Schistosoma mansoni	serine/threonine protein kinase	0.0984	1	1
Onchocerca volvulus		0.0984	1	1
Entamoeba histolytica	protein kinase, putative	0.007	0.0258	0.2578
Brugia malayi	cyclin-dependent kinase 9	0.0103	0.0614	0.0514
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.0695	1
Leishmania major	protein kinase, putative	0.007	0.0258	0.2578
Trichomonas vaginalis	cyclin B, putative	0.008	0.0364	0.0272
Toxoplasma gondii	aurora kinase	0.007	0.0258	1
Trypanosoma cruzi	CYC2-like cyclin, putative	0.008	0.0364	0.4391
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0695	0.0606
Entamoeba histolytica	protein kinase, putative	0.007	0.0258	0.2578
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0106	0.0011
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0103	0.0614	0.0614
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.008	0.0364	0.4391
Trichomonas vaginalis	CMGC family protein kinase	0.0984	1	1
Trichomonas vaginalis	cyclin B, putative	0.008	0.0364	0.0272
Entamoeba histolytica	protein kinase , putative	0.007	0.0258	0.2578
Echinococcus multilocularis	cyclin dependent kinase 9	0.0103	0.0614	0.0514
Plasmodium falciparum	serine/threonine protein kinase, putative	0.007	0.0258	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0695	0.0606
Trichomonas vaginalis	AGC family protein kinase	0.007	0.0258	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0009	0.0009
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.007	0.0258	0.0154
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.0695	0.0596
Onchocerca volvulus		0.0984	1	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0364	0.0364
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.007	0.0258	0.2578
Echinococcus multilocularis	aurora kinase A	0.007	0.0258	0.0154
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.007	0.0258	0.2578
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0111	0.0695	1
Echinococcus multilocularis	cyclin B	0.008	0.0364	0.0262
Brugia malayi	Cyclin, N-terminal domain containing protein	0.008	0.0364	0.0262
Loa Loa (eye worm)	AUR protein kinase	0.007	0.0258	0.0258
Trichomonas vaginalis	cyclins, putative	0.008	0.0364	0.0272
Echinococcus granulosus	cyclin dependent kinase 9	0.0103	0.0614	0.0514
Trichomonas vaginalis	AGC family protein kinase	0.007	0.0258	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.0258	0.0154
Giardia lamblia	G2/mitotic-specific cyclin B	0.008	0.0364	0.0262
Trichomonas vaginalis	cyclin A, putative	0.008	0.0364	0.0272
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0695	0.0606
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0056	0.0106	0.0106
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0106	0.0011
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.0695	0.0596
Echinococcus multilocularis	CDC7 cell division cycle 7	0.0984	1	1
Trypanosoma cruzi	cyclin, putative	0.008	0.0364	0.4391
Entamoeba histolytica	cell division protein kinase 2, putative	0.0072	0.0281	0.2967
Schistosoma mansoni	cyclin B	0.008	0.0364	0.0262
Trichomonas vaginalis	cyclins, putative	0.008	0.0364	0.0272
Schistosoma mansoni	kinase	0.0061	0.0163	0.0058
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.007	0.0258	1
Echinococcus granulosus	cyclin dependent kinase 9	0.012	0.0789	0.0691
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.007	0.0258	0.2578
Giardia lamblia	Kinase, CDC7	0.0984	1	1
Trichomonas vaginalis	cyclins, putative	0.008	0.0364	0.0272
Trichomonas vaginalis	AGC family protein kinase	0.007	0.0258	0.0165
Echinococcus granulosus	cyclin B	0.008	0.0364	0.0262
Schistosoma mansoni	protein kinase	0.007	0.0258	0.0154
Trypanosoma brucei	polo-like protein kinase	0.0111	0.0695	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0695	0.0606
Trichomonas vaginalis	cyclin B, putative	0.008	0.0364	0.0272
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0695	0.0606
Trypanosoma cruzi	aurora B kinase, putative	0.007	0.0258	0.2578
Trypanosoma cruzi	cyclin 6, putative	0.008	0.0364	0.4391
Loa Loa (eye worm)	CDC7 protein kinase	0.0984	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.0614	0.0514
Trichomonas vaginalis	CAMK family protein kinase	0.0127	0.087	0.0783
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.0695	1
Brugia malayi	serine/threonine-protein kinase 6	0.007	0.0258	0.0154
Trypanosoma brucei	mitotic cyclin 6	0.008	0.0364	0.4391
Trichomonas vaginalis	cyclins, putative	0.008	0.0364	0.0272
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.0695	0.0596
Trypanosoma brucei	aurora B kinase	0.007	0.0258	0.2578
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0149	0.0055
Brugia malayi	Cyclin, N-terminal domain containing protein	0.008	0.0364	0.0262
Loa Loa (eye worm)	AUR protein kinase	0.007	0.0258	0.0258
Trichomonas vaginalis	cyclin B, putative	0.008	0.0364	0.0272
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.007	0.0258	0.0154
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.0695	0.0343
Giardia lamblia	Aurora kinase	0.007	0.0258	0.0154
Schistosoma mansoni	kinase	0.0103	0.0614	0.0514
Trypanosoma cruzi	cyclin, putative	0.008	0.0364	0.4391
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0056	0.0106	0.0106
Trichomonas vaginalis	AGC family protein kinase	0.007	0.0258	0.0165
Entamoeba histolytica	protein kinase domain containing protein	0.007	0.0258	0.2578
Echinococcus multilocularis	cyclin dependent kinase 9	0.012	0.0789	0.0691
Echinococcus granulosus	aurora kinase A	0.007	0.0258	0.0154
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.0695	0.0596
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0149	0.0055
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.0695	0.0606
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0106	0.0011
Entamoeba histolytica	protein kinase domain containing protein	0.0103	0.0614	0.8626
Brugia malayi	serine/threonine kinase 12	0.007	0.0258	0.0154
Loa Loa (eye worm)	AUR protein kinase	0.007	0.0258	0.0258

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 878805