Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0309 | 0.0715 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0719 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0309 | 0.5 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0184 | 0.2342 | 0.2342 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0184 | 0.2342 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0719 | 1 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0184 | 0.2342 | 1 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0396 | 0.5372 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0719 | 1 | 1 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0396 | 0.5372 | 0.5372 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0396 | 0.5372 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.0148 | 0.0148 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0309 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.0148 | 0.0148 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0396 | 0.5372 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0148 | 0.4792 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0031 | 0.0148 | 0.0148 |
Trypanosoma brucei | squalene synthase, putative | 0.0592 | 0.8176 | 0.8148 |
Mycobacterium leprae | putative cytochrome p450 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.4325 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0031 | 0.0148 | 0.0632 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0309 | 0.5 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0184 | 0.2342 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0396 | 0.5372 | 0.5303 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0148 | 0.0632 |
Trypanosoma brucei | RNA helicase, putative | 0.0323 | 0.4325 | 0.424 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0719 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0309 | 1 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0396 | 0.5372 | 0.5372 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0148 | 0.4792 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.2342 | 1 |
Leishmania major | squalene synthase, putative | 0.0592 | 0.8176 | 0.8176 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0309 | 0.0715 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0184 | 0.2342 | 0.2342 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0184 | 0.2342 | 0.2342 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0719 | 1 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0592 | 0.8176 | 0.8176 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0309 | 0.132 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0396 | 0.5372 | 0.5303 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0396 | 0.5372 | 0.5 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0396 | 0.5372 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0.0148 | 0.0148 |
Trypanosoma cruzi | squalene synthase, putative | 0.0592 | 0.8176 | 0.8176 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.2342 | 0.5416 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0396 | 0.5372 | 0.5372 |
Leishmania major | hypothetical protein, conserved | 0.0184 | 0.2342 | 0.2342 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0148 | 0.0632 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0309 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0309 | 0.132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.