Detailed information for compound 881293

Basic information

Technical information
  • TDR Targets ID: 881293
  • Name: ethyl 2-[(2-tert-butylphenyl)carbamoylamino]- 3-(phenylmethylsulfanyl)propanoate
  • MW: 414.561 | Formula: C23H30N2O3S
  • H donors: 2 H acceptors: 2 LogP: 5.06 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(NC(=O)Nc1ccccc1C(C)(C)C)CSCc1ccccc1
  • InChi: 1S/C23H30N2O3S/c1-5-28-21(26)20(16-29-15-17-11-7-6-8-12-17)25-22(27)24-19-14-10-9-13-18(19)23(2,3)4/h6-14,20H,5,15-16H2,1-4H3,(H2,24,25,27)
  • InChiKey: RXVNOFLNTIRPMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[[(2-tert-butylphenyl)amino]-oxomethyl]amino]-3-(phenylmethylthio)propanoic acid ethyl ester
  • 3-(benzylthio)-2-[(2-tert-butylphenyl)carbamoylamino]propionic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase shark 0.0543 0.1182 0.1178
Loa Loa (eye worm) hypothetical protein 0.0116 0.0103 0.0137
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Echinococcus multilocularis cyclin dependent kinase 5 0.0151 0.0192 0.0188
Loa Loa (eye worm) TK/INSR protein kinase 0.0418 0.0865 0.1195
Trypanosoma brucei aurora B kinase 0.1276 0.3034 1
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Mycobacterium ulcerans hydrolase 0.1106 0.2606 0.5
Schistosoma mansoni tyrosine kinase 0.0335 0.0655 0.1517
Echinococcus granulosus ephrin type A receptor 4 A 0.0185 0.0277 0.0273
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.1276 0.3034 1
Brugia malayi hypothetical protein 0.0091 0.0038 0.0047
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Trypanosoma cruzi cdc2-related kinase 3 0.0151 0.0192 0.0288
Loa Loa (eye worm) TK/EPH protein kinase 0.0189 0.0287 0.0393
Echinococcus granulosus nervana 2 0.0102 0.0067 0.0063
Echinococcus granulosus tyrosine protein kinase ABL1 0.0316 0.0609 0.0604
Brugia malayi Protein kinase domain containing protein 0.0091 0.0038 0.0047
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.0197 0.0193
Loa Loa (eye worm) hypothetical protein 0.1774 0.4294 0.5959
Trichomonas vaginalis AGC family protein kinase 0.1276 0.3034 1
Echinococcus granulosus Glutaredoxin protein 5 0.0102 0.0067 0.0063
Echinococcus granulosus serine:threonine protein kinase 12 B 0.1276 0.3034 0.3031
Schistosoma mansoni tyrosine kinase 0.0493 0.1057 0.2454
Loa Loa (eye worm) hypothetical protein 0.0127 0.0131 0.0176
Trypanosoma cruzi cdc2-related kinase 1 0.0151 0.0192 0.0288
Entamoeba histolytica protein kinase, putative 0.0103 0.0069 0.0103
Schistosoma mansoni vesicular amine transporter 0.0096 0.0052 0.0111
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0151 0.0192 0.0261
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0335 0.0655 0.0651
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0151 0.0192 0.024
Onchocerca volvulus Tyrosine kinase homolog 0.1042 0.2443 0.341
Echinococcus granulosus tyrosine protein kinase Src42A 0.0111 0.0091 0.0087
Echinococcus multilocularis tyrosine protein kinase Src42A 0.018 0.0264 0.026
Echinococcus granulosus Immunoglobulin 0.0096 0.0052 0.0048
Schistosoma mansoni cell adhesion molecule 0.0152 0.0193 0.044
Trypanosoma cruzi cdc2-related kinase 3 0.0151 0.0192 0.0288
Entamoeba histolytica cell division protein kinase 2, putative 0.0151 0.0192 0.0513
Brugia malayi Protein kinase domain containing protein 0.0177 0.0258 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0192 0.0437
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0096 0.0052 0.0048
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0118 0.0108 0.0241
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0111 0.0091 0.0087
Plasmodium falciparum serine/threonine protein kinase, putative 0.1276 0.3034 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0217 0.0357 0.0853
Echinococcus multilocularis cyclin dependent kinase 0.0151 0.0192 0.0188
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.0197 0.0305
Onchocerca volvulus 0.1151 0.2719 0.3801
Entamoeba histolytica protein kinase, putative 0.0177 0.0258 0.0732
Echinococcus multilocularis tyrosine protein kinase Abl 0.0204 0.0326 0.0322
Echinococcus granulosus serine/threonine protein kinase 0.0125 0.0126 0.0122
Brugia malayi hypothetical protein 0.0126 0.0128 0.0171
Echinococcus granulosus tyrosine protein kinase Srms 0.0091 0.0038 0.0034
Plasmodium falciparum protein kinase 5 0.0151 0.0192 0.0288
Echinococcus granulosus insulin receptor 0.0418 0.0865 0.0861
Brugia malayi serine/threonine-protein kinase 6 0.1276 0.3034 0.4209
Echinococcus granulosus epidermal growth factor receptor 0.0335 0.0655 0.0651
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.01 0.0331
Leishmania major protein kinase, putative 0.1276 0.3034 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.018 0.0264 0.026
Echinococcus granulosus defective proboscis extension response 0.0096 0.0052 0.0048
Brugia malayi cell division control protein 2 homolog 0.0151 0.0192 0.0261
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.0126 0.0293
Schistosoma mansoni tyrosine kinase 0.0266 0.0483 0.1116
Echinococcus granulosus tyrosine protein kinase Fyn 0.018 0.0264 0.026
Echinococcus granulosus cyclin dependent kinase 0.0151 0.0192 0.0188
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.018 0.0264 0.026
Brugia malayi Protein kinase domain containing protein 0.0091 0.0038 0.0047
Echinococcus multilocularis Immunoglobulin 0.0096 0.0052 0.0048
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0125 0.0126 0.0063
Loa Loa (eye worm) hypothetical protein 0.0126 0.0128 0.0171
Brugia malayi Protein kinase domain containing protein 0.0091 0.0038 0.0047
Giardia lamblia Kinase, CMGC MAPK 0.0124 0.0122 0.0049
Trichomonas vaginalis AGC family protein kinase 0.1276 0.3034 1
Echinococcus multilocularis insulin receptor 0.0418 0.0865 0.0861
Echinococcus multilocularis nervana 2 0.0102 0.0067 0.0063
Echinococcus multilocularis tyrosine kinase 0.0091 0.0038 0.0034
Loa Loa (eye worm) TK/ABL protein kinase 0.0316 0.0609 0.0839
Brugia malayi serine/threonine protein kinase 6 0.1276 0.3034 0.4209
Entamoeba histolytica protein kinase, putative 0.1276 0.3034 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0102 0.0067 0.0063
Trypanosoma cruzi polo-like protein kinase, putative 0.0217 0.0357 0.0853
Loa Loa (eye worm) hypothetical protein 0.1106 0.2606 0.3614
Echinococcus multilocularis cyclin dependent kinase 1 0.0151 0.0192 0.0188
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0448 0.0941 0.0937
Giardia lamblia Aurora kinase 0.1276 0.3034 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.018 0.0264 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0122 0.0403
Echinococcus granulosus mitogen activated protein kinase 11 0.0153 0.0197 0.0193
Echinococcus granulosus neuroglian 0.0113 0.0095 0.009
Echinococcus multilocularis mitogen activated protein kinase 0.0124 0.0122 0.0118
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0152 0.0195 0.019
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0102 0.0067 0.0063
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0401 0.0823 0.0819
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0217 0.0357 0.0808
Loa Loa (eye worm) matrixin family protein 0.2015 0.4903 0.6804
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0357 0.0823
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0124 0.0122 0.0049
Loa Loa (eye worm) hypothetical protein 0.0126 0.0128 0.0171
Echinococcus multilocularis tyrosine protein kinase Src64B 0.018 0.0264 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Echinococcus granulosus twitchin 0.0129 0.0136 0.0131
Schistosoma mansoni tyrosine kinase 0.0543 0.1182 0.2746
Brugia malayi Protein kinase domain containing protein 0.0193 0.0297 0.0407
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Brugia malayi Tyrosine-protein kinase abl-1 0.0139 0.0162 0.0218
Schistosoma mansoni protein kinase 0.1276 0.3034 0.7064
Echinococcus multilocularis ephrin type A receptor 4 A 0.0185 0.0277 0.0273
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0506 0.109 0.1086
Echinococcus multilocularis Immunoglobulin 0.0096 0.0052 0.0048
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.1106 0.2606 0.3614
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0102 0.0067 0.0063
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0118 0.0108 0.0103
Echinococcus multilocularis epidermal growth factor receptor 0.0335 0.0655 0.0651
Brugia malayi serine/threonine-protein kinase plk-2 0.0217 0.0357 0.049
Echinococcus multilocularis epidermal growth factor receptor 0.0482 0.1027 0.1023
Schistosoma mansoni ephrin receptor 0.0157 0.0207 0.0472
Brugia malayi protein-tyrosine kinase 0.0152 0.0195 0.0264
Trichomonas vaginalis AGC family protein kinase 0.1276 0.3034 1
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.018 0.0264 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0122 0.0274
Schistosoma mansoni tyrosine kinase 0.018 0.0264 0.0606
Onchocerca volvulus Serine\/threonine kinase homolog 0.0217 0.0357 0.0452
Brugia malayi Matrixin family protein 0.0908 0.2106 0.2919
Brugia malayi Stress-activated protein kinase jnk-1 0.0506 0.109 0.1507
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.1276 0.3034 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0217 0.0357 0.049
Schistosoma mansoni serine/threonine-protein kinase 0.0125 0.0126 0.0284
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.0197 0.0193
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0636 0.1416 0.3291
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1774 0.4294 1
Brugia malayi p70 ribosomal S6 kinase beta 0.017 0.0239 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Schistosoma mansoni tyrosine kinase 0.0482 0.1027 0.2384
Entamoeba histolytica PH domain containing protein kinase, putative 0.0125 0.0126 0.0293
Schistosoma mansoni tyrosine kinase 0.0294 0.0552 0.1276
Loa Loa (eye worm) AUR protein kinase 0.1276 0.3034 0.4209
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0151 0.0192 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0122 0.0403
Onchocerca volvulus 0.0116 0.0103 0.0092
Onchocerca volvulus Matrilysin homolog 0.0908 0.2106 0.2932
Echinococcus granulosus tyrosine protein kinase Blk 0.0152 0.0195 0.019
Brugia malayi Furin-like cysteine rich region family protein 0.0482 0.1027 0.1421
Echinococcus multilocularis aurora kinase A 0.1276 0.3034 0.3031
Trypanosoma brucei polo-like protein kinase 0.0217 0.0357 0.0808
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0091 0.0038 0.0034
Echinococcus multilocularis c src tyrosine kinase 0.0118 0.0108 0.0103
Echinococcus granulosus epidermal growth factor receptor 0.0482 0.1027 0.1023
Entamoeba histolytica protein kinase domain containing protein 0.1276 0.3034 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0122 0.0117 0.0113
Echinococcus granulosus nervana 2 0.0102 0.0067 0.0063
Echinococcus granulosus tyrosine protein kinase Fyn 0.018 0.0264 0.026
Echinococcus granulosus mitogen activated protein kinase 14 0.0153 0.0197 0.0193
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Mycobacterium leprae PROBABLE HYDROLASE 0.1106 0.2606 0.5
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0151 0.0192 0.0261
Echinococcus multilocularis tyrosine protein kinase Srms 0.0152 0.0195 0.019
Giardia lamblia Kinase, CMGC CDK 0.0151 0.0192 0.0288
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0506 0.109 0.1507
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0122 0.0403
Giardia lamblia Kinase, CMGC CDK 0.0151 0.0192 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.01 0.0331
Echinococcus granulosus tyrosine protein kinase HCK 0.0103 0.0069 0.0065
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Echinococcus granulosus tyrosine kinase 0.0091 0.0038 0.0034
Onchocerca volvulus Matrix metalloproteinase homolog 0.2015 0.4903 0.6897
Echinococcus granulosus c-Jun N-terminal kinases 0.0506 0.109 0.1086
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.018 0.0264 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Loa Loa (eye worm) TK/EGFR protein kinase 0.0482 0.1027 0.1421
Loa Loa (eye worm) hypothetical protein 0.0085 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0091 0.0038 0.0047
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0153 0.0197 0.0257
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0217 0.0357 0.0353
Schistosoma mansoni tyrosine kinase 0.018 0.0264 0.0606
Echinococcus granulosus roundabout 2 0.0169 0.0236 0.0232
Brugia malayi Matrixin family protein 0.0908 0.2106 0.2919
Loa Loa (eye worm) AUR protein kinase 0.1276 0.3034 0.4209
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0153 0.0197 0.0257
Schistosoma mansoni nephrin 0.0143 0.0171 0.0388
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0448 0.0941 0.0937
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.0197 0.0193
Echinococcus multilocularis mitogen activated protein kinase 3 0.0124 0.0122 0.0118
Entamoeba histolytica serine/threonine protein kinase, putative 0.0217 0.0357 0.1065
Entamoeba histolytica protein kinase 2, putative 0.0118 0.0108 0.0232
Trypanosoma brucei rac serine-threonine kinase, putative 0.0177 0.0258 0.0465
Brugia malayi P38 map kinase family protein 2 0.0153 0.0197 0.0267
Loa Loa (eye worm) hypothetical protein 0.0126 0.0128 0.0171
Brugia malayi MAP kinase sur-1 0.0124 0.0122 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.109 0.253
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0122 0.0403
Entamoeba histolytica cell division protein kinase 2, putative 0.0151 0.0192 0.0513
Brugia malayi ephrin receptor 1 precursor 0.0096 0.0051 0.0065
Echinococcus granulosus tyrosine protein kinase Fyn 0.018 0.0264 0.026
Brugia malayi Hemopexin family protein 0.1151 0.2719 0.377
Entamoeba histolytica protein kinase, putative 0.1276 0.3034 1
Trypanosoma brucei cdc2-related kinase 1 0.0151 0.0192 0.024
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0401 0.0823 0.0819
Echinococcus multilocularis tyrosine protein kinase Fyn 0.018 0.0264 0.026
Entamoeba histolytica protein kinase, putative 0.0177 0.0258 0.0732
Brugia malayi Protein kinase domain containing protein 0.0418 0.0865 0.1195
Echinococcus multilocularis tyrosine protein kinase shark 0.0543 0.1182 0.1178
Schistosoma mansoni tyrosine kinase 0.0418 0.0865 0.2006
Schistosoma mansoni serine/threonine protein kinase 0.1276 0.3034 0.7064
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0151 0.0192 0.024
Brugia malayi serine/threonine kinase 12 0.1276 0.3034 0.4209
Onchocerca volvulus 0.0908 0.2106 0.2932
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Trypanosoma cruzi cdc2-related kinase 1 0.0151 0.0192 0.0288
Schistosoma mansoni serine/threonine-protein kinase 0.0125 0.0126 0.0284
Echinococcus granulosus aurora kinase A 0.1276 0.3034 0.3031
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0192 0.0633
Onchocerca volvulus 0.0984 0.2297 0.3203
Loa Loa (eye worm) AGC/AKT protein kinase 0.0177 0.0258 0.0352
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.0197 0.0305
Loa Loa (eye worm) matrixin family protein 0.2925 0.7203 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.1276 0.3034 1
Trypanosoma cruzi Protein kinase B 0.0125 0.0126 0.0063
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.1106 0.2606 0.5
Echinococcus multilocularis roundabout 2 0.0169 0.0236 0.0232
Schistosoma mansoni tyrosine kinase 0.0294 0.0552 0.1276
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Brugia malayi Matrixin family protein 0.2925 0.7203 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0194 0.0263
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.1276 0.3034 0.3031
Loa Loa (eye worm) SRC-1 0.018 0.0264 0.0361
Echinococcus multilocularis neuroglian 0.0113 0.0095 0.009
Schistosoma mansoni kinase 0.0118 0.0107 0.0239
Echinococcus granulosus cyclin dependent kinase 5 0.0151 0.0192 0.0188
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Schistosoma mansoni hypothetical protein 0.1151 0.2719 0.6328
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0192 0.0437
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0151 0.0192 0.024
Loa Loa (eye worm) hypothetical protein 0.0135 0.0151 0.0204
Brugia malayi Matrixin family protein 0.0908 0.2106 0.2919
Echinococcus multilocularis tyrosine protein kinase Fyn 0.018 0.0264 0.026
Echinococcus granulosus tyrosine protein kinase Lyn 0.0196 0.0305 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Brugia malayi Matrixin family protein 0.0908 0.2106 0.2919
Echinococcus granulosus mitogen activated protein kinase 0.0124 0.0122 0.0118
Echinococcus granulosus c src tyrosine kinase 0.0118 0.0108 0.0103
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.1276 0.3034 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0118 0.0108 0.0103
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0152 0.0195 0.019
Brugia malayi Protein kinase domain containing protein 0.0151 0.0192 0.0261
Loa Loa (eye worm) hypothetical protein 0.0139 0.016 0.0216
Echinococcus granulosus cyclin dependent kinase 1 0.0151 0.0192 0.0188
Loa Loa (eye worm) hypothetical protein 0.0908 0.2106 0.2919
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Giardia lamblia Kinase, PLK 0.0217 0.0357 0.0853
Brugia malayi Immunoglobulin I-set domain containing protein 0.1147 0.2708 0.3756
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0091 0.0038 0.0034
Schistosoma mansoni tyrosine kinase 0.0418 0.0865 0.2006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0124 0.0122 0.0049
Echinococcus multilocularis 0.0135 0.015 0.0146
Schistosoma mansoni tyrosine kinase 0.0118 0.0108 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0192 0.0633
Loa Loa (eye worm) matrix metalloproteinase 0.0908 0.2106 0.2919
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.4031 1 1
Echinococcus multilocularis nervana 2 0.0102 0.0067 0.0063
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.018 0.0264 0.026
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Schistosoma mansoni tyrosine kinase 0.0335 0.0655 0.1517
Toxoplasma gondii aurora kinase 0.1276 0.3034 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0151 0.0192 0.0188
Loa Loa (eye worm) hypothetical protein 0.0096 0.0052 0.0066
Trypanosoma brucei cdc2-related kinase 3 0.0151 0.0192 0.024
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1097 0.2584 0.258
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1147 0.2708 0.3756
Onchocerca volvulus Matrilysin homolog 0.288 0.7091 1
Schistosoma mansoni tyrosine kinase 0.0294 0.0552 0.1276
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0089 0.0034 0.0041
Brugia malayi Tyrosine-protein kinase abl-1 0.0204 0.0326 0.0447
Loa Loa (eye worm) hypothetical protein 0.0139 0.016 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Loa Loa (eye worm) hypothetical protein 0.0096 0.0052 0.0066
Loa Loa (eye worm) hypothetical protein 0.0908 0.2106 0.2919
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0124 0.0122 0.0049
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.017 0.0239 0.0326
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.018 0.0264 0.026
Echinococcus multilocularis tyrosine protein kinase Fgr 0.018 0.0264 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.0357 0.1178
Brugia malayi SH2 domain containing protein 0.0091 0.0038 0.0047
Echinococcus granulosus mitogen activated protein kinase 3 0.0124 0.0122 0.0118
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0151 0.0192 0.0261
Loa Loa (eye worm) AUR protein kinase 0.1276 0.3034 0.4209
Loa Loa (eye worm) TK/FER protein kinase 0.0091 0.0038 0.0047
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0153 0.0197 0.0267
Toxoplasma gondii AGC kinase 0.017 0.0239 0.0402
Echinococcus multilocularis rac serine:threonine kinase 0.0125 0.0126 0.0122
Loa Loa (eye worm) hypothetical protein 0.0096 0.0052 0.0066
Schistosoma mansoni tyrosine kinase 0.0118 0.0108 0.0241
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.018 0.0264 0.026
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0217 0.0357 0.0353
Schistosoma mansoni tyrosine kinase 0.0373 0.0753 0.1745
Brugia malayi Protein kinase domain containing protein 0.0091 0.0038 0.0047
Entamoeba histolytica protein kinase, putative 0.017 0.0239 0.0671
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0124 0.0122 0.0163
Brugia malayi SRC-1 0.018 0.0264 0.0361
Loa Loa (eye worm) hypothetical protein 0.0122 0.0117 0.0157
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0096 0.0052 0.0111
Echinococcus multilocularis tyrosine protein kinase HCK 0.0103 0.0069 0.0065
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.0197 0.0193
Brugia malayi Fibronectin type III domain containing protein 0.0126 0.0128 0.0171
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0096 0.0052 0.0111
Schistosoma mansoni TPX2 protein 0.1123 0.2647 0.6162
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0258 0.0849
Plasmodium vivax protein kinase Crk2 0.0151 0.0192 0.0288
Echinococcus multilocularis tyrosine protein kinase Blk 0.0152 0.0195 0.019
Brugia malayi SH2 domain containing protein 0.0091 0.0038 0.0047
Loa Loa (eye worm) TK protein kinase 0.0152 0.0195 0.0264
Trichomonas vaginalis AGC family protein kinase 0.1276 0.3034 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0316 0.0609 0.0604
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0128 0.0171
Echinococcus granulosus serine threonine protein kinase nrc 0.0118 0.0108 0.0103
Brugia malayi Protein kinase domain containing protein 0.0091 0.0038 0.0047
Trypanosoma cruzi aurora B kinase, putative 0.1276 0.3034 1
Schistosoma mansoni tyrosine kinase 0.0084 0.0021 0.0038
Echinococcus granulosus tyrosine kinase 0.0152 0.0195 0.019
Loa Loa (eye worm) TK protein kinase 0.0103 0.0069 0.009
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0192 0.0633
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0124 0.0122 0.0049
Entamoeba histolytica protein kinase , putative 0.1276 0.3034 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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