Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hexokinase, putative | 0.0373 | 0.1279 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0486 | 0.2502 | 0.1402 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1181 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1181 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0373 | 0.1279 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0554 | 0.3234 | 1 |
Echinococcus multilocularis | protein patched | 0.0486 | 0.2502 | 0.1402 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0486 | 0.2502 | 0.1402 |
Onchocerca volvulus | 0.0373 | 0.1279 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1181 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0373 | 0.1279 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0554 | 0.3234 | 1 |
Plasmodium falciparum | hexokinase | 0.0373 | 0.1279 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0373 | 0.1279 | 0.1279 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1181 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0373 | 0.1279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1181 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0486 | 0.2502 | 0.1402 |
Loa Loa (eye worm) | hexokinase | 0.0373 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0486 | 0.2502 | 0.2502 |
Brugia malayi | CHE-14 protein | 0.0486 | 0.2502 | 0.1402 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0554 | 0.3234 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1181 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0554 | 0.3234 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0373 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.2502 | 0.2502 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1181 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0486 | 0.2502 | 0.1402 |
Entamoeba histolytica | hexokinase 1 | 0.0373 | 0.1279 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0486 | 0.2502 | 0.1402 |
Echinococcus multilocularis | protein dispatched 1 | 0.0486 | 0.2502 | 0.1402 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0486 | 0.2502 | 0.1402 |
Onchocerca volvulus | 0.0373 | 0.1279 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1181 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0486 | 0.2502 | 0.1402 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1181 | 1 | 1 |
Onchocerca volvulus | 0.0373 | 0.1279 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.