Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0112 | 0.2149 | 0.1925 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0294 | 0.635 | 0.635 |
Schistosoma mansoni | tyrosine kinase | 0.0294 | 0.635 | 0.6245 |
Entamoeba histolytica | protein kinase, putative | 0.0112 | 0.2149 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0112 | 0.2149 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0367 | 0.8017 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0112 | 0.2149 | 0.2418 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0163 | 0.3337 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0156 | 0.3162 | 0.2967 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0095 | 0.1765 | 0.1921 |
Onchocerca volvulus | 0.003 | 0.0278 | 0.5 | |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0095 | 0.1765 | 0.1921 |
Toxoplasma gondii | aurora kinase | 0.0112 | 0.2149 | 0.5 |
Leishmania major | protein kinase, putative | 0.0112 | 0.2149 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.215 | 0.1925 |
Echinococcus multilocularis | 0.0091 | 0.1665 | 0.1793 | |
Schistosoma mansoni | tyrosine kinase | 0.0156 | 0.3162 | 0.2967 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0286 | 0.6161 | 0.7602 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0112 | 0.2149 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0294 | 0.635 | 0.7846 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0112 | 0.2149 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0294 | 0.635 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0159 | 0.3232 | 0.3817 |
Loa Loa (eye worm) | AUR protein kinase | 0.0112 | 0.2149 | 0.3385 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0095 | 0.1765 | 0.2779 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0139 | 0.2766 | 0.2559 |
Giardia lamblia | Aurora kinase | 0.0112 | 0.2149 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0112 | 0.2149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1563 | 0.2461 |
Schistosoma mansoni | tyrosine kinase | 0.0095 | 0.1765 | 0.1529 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0112 | 0.2149 | 0.2149 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.6161 | 0.9703 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0112 | 0.2149 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0112 | 0.2149 | 0.2149 |
Schistosoma mansoni | tyrosine kinase | 0.0156 | 0.3162 | 0.2967 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0163 | 0.3337 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0367 | 0.8017 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0112 | 0.2149 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0112 | 0.2149 | 0.2418 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.3232 | 0.3039 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1481 | 0.2332 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0112 | 0.2149 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0159 | 0.3232 | 0.3817 |
Schistosoma mansoni | ryanodine receptor related | 0.0453 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0112 | 0.2149 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0112 | 0.2149 | 0.2418 |
Brugia malayi | cation channel family protein | 0.0194 | 0.4035 | 0.4035 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0052 | 0.0783 | 0.0519 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.2149 | 0.1925 |
Schistosoma mansoni | tyrosine kinase | 0.0095 | 0.1765 | 0.1529 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.1765 | 0.1765 |
Trichomonas vaginalis | AGC family protein kinase | 0.0112 | 0.2149 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0169 | 0.3472 | 0.5468 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0112 | 0.2149 | 0.2418 |
Loa Loa (eye worm) | AUR protein kinase | 0.0112 | 0.2149 | 0.3385 |
Trichomonas vaginalis | AGC family protein kinase | 0.0112 | 0.2149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0849 | 0.1337 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.3232 | 0.3039 |
Loa Loa (eye worm) | ryanodine receptor | 0.0107 | 0.2039 | 0.3211 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0159 | 0.3232 | 0.3817 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0294 | 0.635 | 0.7846 |
Entamoeba histolytica | protein kinase, putative | 0.0112 | 0.2149 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0286 | 0.6161 | 0.7602 |
Brugia malayi | MIR domain containing protein | 0.003 | 0.0278 | 0.0278 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0112 | 0.2149 | 0.2149 |
Loa Loa (eye worm) | AUR protein kinase | 0.0112 | 0.2149 | 0.3385 |
Echinococcus granulosus | insulin receptor | 0.0095 | 0.1765 | 0.1921 |
Echinococcus multilocularis | insulin receptor | 0.0095 | 0.1765 | 0.1921 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.003 | 0.0278 | 0.0437 |
Entamoeba histolytica | protein kinase , putative | 0.0112 | 0.2149 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0055 | 0.0849 | 0.0588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.