Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | bHLH-PAS transcription factor | 0.0074 | 0.0206 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.1791 | 0.8232 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0163 | 0.0745 | 0.5 |
Schistosoma mansoni | single-minded | 0.01 | 0.0364 | 0.1671 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0399 | 0.2176 | 1 |
Mycobacterium ulcerans | proteasome PrcA | 0.169 | 1 | 1 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0163 | 0.0745 | 0.3421 |
Brugia malayi | hypoxia-induced factor 1 | 0.031 | 0.1634 | 0.7508 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0163 | 0.0745 | 0.5 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0149 | 0.0659 | 0.0659 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0163 | 0.0745 | 0.3421 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0399 | 0.2176 | 1 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0163 | 0.0745 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.0206 | 0.7193 | |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0163 | 0.0745 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0399 | 0.2176 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0163 | 0.0745 | 1 |
Brugia malayi | hypothetical protein | 0.0336 | 0.1791 | 0.8232 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.01 | 0.0364 | 0.1671 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0163 | 0.0745 | 0.5 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0163 | 0.0745 | 0.5 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0163 | 0.0745 | 0.0745 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0163 | 0.0745 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.031 | 0.1634 | 0.7508 |
Brugia malayi | PAS domain containing protein | 0.01 | 0.0364 | 0.1671 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0163 | 0.0745 | 0.0745 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0163 | 0.0745 | 0.2733 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0163 | 0.0745 | 0.3421 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.0659 | 0.3027 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0399 | 0.2176 | 1 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.169 | 1 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0074 | 0.0206 | 0.0206 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0087 | 0.0286 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0149 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0399 | 0.2176 | 1 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0163 | 0.0745 | 0.2733 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0149 | 0.0659 | 0.2297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.