Detailed information for compound 884080

Basic information

Technical information
  • TDR Targets ID: 884080
  • Name: 2-[(2E)-2-[(3-hydroxyphenyl)methylidene]hydra zinyl]-6-propyl-1H-pyrimidin-4-one
  • MW: 272.302 | Formula: C14H16N4O2
  • H donors: 3 H acceptors: 4 LogP: 2.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc(N/N=C/c2cccc(c2)O)nc(c1)O
  • InChi: 1S/C14H16N4O2/c1-2-4-11-8-13(20)17-14(16-11)18-15-9-10-5-3-6-12(19)7-10/h3,5-9,19H,2,4H2,1H3,(H2,16,17,18,20)/b15-9+
  • InChiKey: KSYSMLSEHFKEOK-OQLLNIDSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[(3-hydroxyphenyl)methylidene]hydrazinyl]-6-propyl-1H-pyrimidin-4-one
  • 2-[(N'E)-N'-[(3-hydroxyphenyl)methylene]hydrazino]-6-propyl-1H-pyrimidin-4-one
  • 2-[N'-[(3-hydroxyphenyl)methylene]hydrazino]-6-propyl-1H-pyrimidin-4-one
  • 2-[(N'E)-N'-(3-hydroxybenzylidene)hydrazino]-6-propyl-1H-pyrimidin-4-one
  • 2-[N'-(3-hydroxybenzylidene)hydrazino]-6-propyl-1H-pyrimidin-4-one
  • ST5188473

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1444 0.2108
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0206 0.685 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0206 0.685 0.6074
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0206 0.685 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1444 0.2108
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0206 0.685 1
Brugia malayi DNA polymerase delta catalytic subunit 0.0206 0.685 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0068 0.1977 0.2886
Onchocerca volvulus DNA polymerase homolog 0.0068 0.1977 0.2886
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0168 0.5518 0.7853
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0068 0.1977 0.2147
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0068 0.1977 0.2886
Toxoplasma gondii DNA polymerase 0.0206 0.685 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0068 0.1977 0.2147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1444 0.2108
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0068 0.1977 0.2147
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.003 0.0645 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1444 0.2108
Brugia malayi DNA polymerase family B containing protein 0.0068 0.1977 0.2886
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.2055 0.3
Loa Loa (eye worm) hypothetical protein 0.0068 0.1977 0.2886
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0206 0.685 1
Toxoplasma gondii DNA polymerase family B protein 0.0068 0.1977 0.2147
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.2055 0.2272
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0068 0.1977 0.2147
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0206 0.685 1
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0068 0.1977 0.2886
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.2055 0.3
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0206 0.685 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.2055 0.5
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0068 0.1977 0.2886
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.2055 0.3
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0068 0.1977 0.2886
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0068 0.1977 0.2886
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0068 0.1977 0.2147
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0068 0.1977 0.2147
Loa Loa (eye worm) hypothetical protein 0.003 0.0645 0.0942
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0206 0.685 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.091 0.1328
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0206 0.685 1
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0068 0.1977 0.2147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1444 0.2108
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1444 0.2108
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0038 0.091 0.0426
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0038 0.091 0.0426
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.2055 0.5
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0068 0.1977 0.2147
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0068 0.1977 0.2147
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0206 0.685 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.091 0.1328
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.2055 0.3
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0206 0.685 1
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0068 0.1977 0.2886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1444 0.2108
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.2055 0.2272
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.2055 0.5
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0068 0.1977 0.2886
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0068 0.1977 0.2886
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0038 0.091 0.1328
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0068 0.1977 0.2886
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0068 0.1977 0.2886
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0068 0.1977 0.2147
Brugia malayi DNA polymerase alpha catalytic subunit 0.0068 0.1977 0.2886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1444 0.2108
Trichomonas vaginalis DNA polymerase II, putative 0.0068 0.1977 0.2147
Loa Loa (eye worm) hypothetical protein 0.003 0.0645 0.0942
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.2055 0.5
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0206 0.685 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0206 0.685 1
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0068 0.1977 0.2886
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1444 0.2108

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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