Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Thymidine kinase | 0.0243 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0894 | 0.3481 | 0.3148 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1879 | 0.8746 | 1 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0348 | 0.0562 | 0.0562 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0348 | 0.0562 | 0.0562 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1879 | 0.8746 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1879 | 0.8746 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0894 | 0.3481 | 0.3148 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2113 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2113 | 1 | 0.5 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0348 | 0.0562 | 0.0562 |
Entamoeba histolytica | thymidine kinase, putative | 0.0243 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2113 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0441 | 0.1062 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1879 | 0.8746 | 1 |
Onchocerca volvulus | 0.1879 | 0.8746 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1879 | 0.8746 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2113 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2113 | 1 | 1 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0348 | 0.0562 | 0.0562 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0894 | 0.3481 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1879 | 0.8746 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0894 | 0.3481 | 0.3481 |
Brugia malayi | thymidylate synthase | 0.1879 | 0.8746 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1879 | 0.8746 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.