Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0347 | 0.6432 | 0.6432 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0202 | 0.3254 | 0.4118 |
Echinococcus granulosus | geminin | 0.0205 | 0.331 | 0.331 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.331 | 0.3618 |
Loa Loa (eye worm) | glutamate receptor | 0.0163 | 0.2402 | 0.2402 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1158 | 0.1158 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0376 | 0.7051 | 0.8921 |
Loa Loa (eye worm) | glutamate receptor | 0.0415 | 0.7904 | 0.7904 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0106 | 0.1158 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0347 | 0.6432 | 0.7031 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.331 | 0.3618 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.051 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0067 | 0.0306 | 0.0306 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0067 | 0.0306 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0067 | 0.0306 | 0.5 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0067 | 0.0306 | 0.0306 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0471 | 0.9147 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0347 | 0.6432 | 0.6432 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0306 | 0.0334 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0415 | 0.7904 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0106 | 0.1158 | 0.1466 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0106 | 0.1158 | 0.1158 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0067 | 0.0306 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0306 | 0.0306 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0202 | 0.3254 | 0.3558 |
Echinococcus multilocularis | geminin | 0.0205 | 0.331 | 0.331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3264 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.1582 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.7781 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.