Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.2134 | 0.4577 | 0.7966 |
Loa Loa (eye worm) | integrin beta-2 | 0.4371 | 1 | 1 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0664 | 0.1014 | 0.0638 |
Echinococcus multilocularis | fibrillin 1 | 0.0553 | 0.0743 | 0.0498 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0561 | 0.0763 | 0.0527 |
Schistosoma mansoni | integrin alpha-ps | 0.0957 | 0.1723 | 0.2521 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0738 | 0.1193 | 0.1154 |
Echinococcus granulosus | integrin alpha 3 | 0.1636 | 0.3369 | 0.4331 |
Brugia malayi | Protein kinase domain containing protein | 0.0561 | 0.0763 | 0.0376 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0494 | 0.0602 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.1177 | 0.2258 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 0.0763 | 0.0376 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0494 | 0.0602 | 0.0293 |
Brugia malayi | Kringle domain containing protein | 0.0561 | 0.0763 | 0.0376 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.2134 | 0.4577 | 0.435 |
Schistosoma mansoni | hypothetical protein | 0.0561 | 0.0763 | 0.0689 |
Leishmania major | hypothetical protein, conserved | 0.0561 | 0.0763 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.329 | 0.7379 | 0.7269 |
Loa Loa (eye worm) | hypothetical protein | 0.1614 | 0.3317 | 0.3037 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1614 | 0.3317 | 0.3037 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0738 | 0.1193 | 0.1509 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0561 | 0.0763 | 0.0376 |
Onchocerca volvulus | 0.0561 | 0.0763 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.1014 | 0.0638 |
Echinococcus multilocularis | integrin beta 2 | 0.3238 | 0.7253 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0561 | 0.0763 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.0611 | 0.0218 |
Schistosoma mansoni | integrin beta subunit | 0.2574 | 0.5643 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0246 | 0 | 0.5 |
Echinococcus multilocularis | integrin alpha 3 | 0.1636 | 0.3369 | 0.4331 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0494 | 0.0602 | 0.0293 |
Echinococcus granulosus | integrin alpha ps | 0.0957 | 0.1723 | 0.1928 |
Schistosoma mansoni | hypothetical protein | 0.0459 | 0.0515 | 0.0217 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0561 | 0.0763 | 0.0527 |
Echinococcus granulosus | integrin alpha ps | 0.0459 | 0.0515 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.0515 | 0.0118 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0738 | 0.1193 | 0.1154 |
Brugia malayi | hypothetical protein | 0.0664 | 0.1014 | 0.0638 |
Echinococcus multilocularis | integrin alpha ps | 0.0957 | 0.1723 | 0.1928 |
Echinococcus granulosus | neuropeptide s receptor | 0.0494 | 0.0602 | 0.0293 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0561 | 0.0763 | 0.5 |
Brugia malayi | Kelch motif family protein | 0.0664 | 0.1014 | 0.0638 |
Echinococcus multilocularis | integrin alpha ps | 0.0459 | 0.0515 | 0.0166 |
Schistosoma mansoni | integrin alpha-ps | 0.0498 | 0.0611 | 0.04 |
Toxoplasma gondii | kringle domain-containing protein | 0.0561 | 0.0763 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1675 | 0.3465 | 0.3192 |
Echinococcus multilocularis | integrin alpha ps | 0.0957 | 0.1723 | 0.1928 |
Echinococcus granulosus | integrin beta 2 | 0.3238 | 0.7253 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0561 | 0.0763 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.