Detailed information for compound 887137

Basic information

Technical information
  • TDR Targets ID: 887137
  • Name: 4-(furan-2-carbonyl)-N-(2-propylphenyl)pipera zine-1-carboxamide
  • MW: 341.404 | Formula: C19H23N3O3
  • H donors: 1 H acceptors: 2 LogP: 2.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1ccccc1NC(=O)N1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C19H23N3O3/c1-2-6-15-7-3-4-8-16(15)20-19(24)22-12-10-21(11-13-22)18(23)17-9-5-14-25-17/h3-5,7-9,14H,2,6,10-13H2,1H3,(H,20,24)
  • InChiKey: IHUIJUIZWIBBKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-furyl-oxomethyl)-N-(2-propylphenyl)-1-piperazinecarboxamide
  • 4-furan-2-ylcarbonyl-N-(2-propylphenyl)piperazine-1-carboxamide
  • Oprea1_134293

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0714 0.2489
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1409 0.4915
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0063 0.1409 0.4915
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0714 0.2489
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0091 0.2867 1
Brugia malayi TAR-binding protein 0.0063 0.1409 0.4915
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1409 0.4915
Onchocerca volvulus 0.0036 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1409 0.4915
Loa Loa (eye worm) hypothetical protein 0.0091 0.2867 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1409 0.4915
Plasmodium vivax hypothetical protein, conserved 0.0036 0 0.5
Onchocerca volvulus 0.0036 0 0.5
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0091 0.2867 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0091 0.2867 1
Brugia malayi CAAX amino terminal protease family protein 0.0091 0.2867 1
Entamoeba histolytica CAAX prenyl protease family 0.0091 0.2867 0.5
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0091 0.2867 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.1409 0.4915
Mycobacterium leprae Probable lipase LipE 0.0036 0 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0714 0.2489
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1409 0.4915
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0091 0.2867 1
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0091 0.2867 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1409 0.4915
Echinococcus multilocularis CAAX prenyl protease 2 0.0091 0.2867 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1409 0.4915
Mycobacterium ulcerans beta-lactamase 0.0036 0 0.5
Giardia lamblia Hypothetical protein 0.0091 0.2867 0.5
Mycobacterium ulcerans hypothetical protein 0.0036 0 0.5
Brugia malayi RNA binding protein 0.0063 0.1409 0.4915
Toxoplasma gondii ABC1 family protein 0.0036 0 0.5
Echinococcus granulosus CAAX prenyl protease 2 0.0091 0.2867 1
Mycobacterium ulcerans lipase LipD 0.0036 0 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0714 0.2489
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1409 0.4915
Onchocerca volvulus 0.0036 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1409 0.4915
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0 0.5
Trypanosoma brucei CAAX amino terminal protease, putative 0.0091 0.2867 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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