Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0988 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0988 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0427 | 0.277 | 0.2254 |
Loa Loa (eye worm) | hypothetical protein | 0.0988 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0212 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0378 | 0.2145 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0264 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0988 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0427 | 0.277 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0427 | 0.277 | 0.277 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0427 | 0.277 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0427 | 0.277 | 0.2254 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0988 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0427 | 0.277 | 0.2254 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0427 | 0.277 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0215 | 0.0042 | 0.0042 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0988 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0988 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0427 | 0.277 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0988 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0988 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0427 | 0.277 | 0.2254 |
Chlamydia trachomatis | sulfite reductase | 0.0264 | 0.0667 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0427 | 0.277 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0427 | 0.277 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0427 | 0.277 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0427 | 0.277 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0212 | 0 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0427 | 0.277 | 0.2254 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0427 | 0.277 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0427 | 0.277 | 0.5 |
Onchocerca volvulus | 0.0988 | 1 | 0.5 | |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0378 | 0.2145 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0988 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0427 | 0.277 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0427 | 0.277 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0427 | 0.277 | 0.2254 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0427 | 0.277 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0427 | 0.277 | 0.2254 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.277 | 0.2254 |
Leishmania major | p450 reductase, putative | 0.0427 | 0.277 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0988 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.