Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2386 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.027 | 0.0552 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0076 | 0.0161 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.12 | 0.4701 | 0.4701 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.12 | 0.4701 | 0.3748 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0076 | 0.0161 |
Echinococcus granulosus | geminin | 0.0164 | 0.0076 | 0.0161 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.12 | 0.4701 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.2386 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2386 | 1 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.12 | 0.4701 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.027 | 0.0552 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2386 | 1 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.12 | 0.4701 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0076 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.122 | 0.4791 | 0.4791 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.12 | 0.4701 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.