Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor kinase 6 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0053 | 0.095 | 0.1513 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0155 | 0.3529 | 0.408 |
Echinococcus multilocularis | kinesin family 1 | 0.0409 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0139 | 0.3137 | 0.3137 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0155 | 0.3529 | 0.5621 |
Entamoeba histolytica | kinesin, putative | 0.0053 | 0.095 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0053 | 0.095 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0053 | 0.095 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0139 | 0.3137 | 0.3137 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0155 | 0.3529 | 0.4841 |
Schistosoma mansoni | hypothetical protein | 0.0356 | 0.8649 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0053 | 0.095 | 0.1098 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0139 | 0.3137 | 0.4997 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0139 | 0.3137 | 0.4997 |
Plasmodium falciparum | kinesin-5 | 0.0053 | 0.095 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0053 | 0.095 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0263 | 0.6278 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0263 | 0.6278 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0139 | 0.3137 | 0.4105 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.52 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 1.522 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | 6.0085 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 6.01 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
IC50 (binding) | = 1.56 uM | Inhibition of human recombinant full-length GST-tagged human GRK6 using peptide substrate peptide-216 incubated for 7 hrs | ChEMBL. | No reference |
Percent growth inhibition (functional) | = 89.2 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 128.1 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.