TDR Targets

Basic information

Technical information

TDR Targets ID: 897972
Name: (4Z)-2-(2-fluorophenyl)-4-[(3-methoxy-4-propo xyphenyl)methylidene]-1,3-oxazol-5-one
MW: 355.36 | Formula: C20H18FNO4
H donors: 0 H acceptors: 1 LogP: 4.5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1OC)C=C1N=C(OC1=O)c1ccccc1F
InChi: 1S/C20H18FNO4/c1-3-10-25-17-9-8-13(12-18(17)24-2)11-16-20(23)26-19(22-16)14-6-4-5-7-15(14)21/h4-9,11-12H,3,10H2,1-2H3/b16-11-
InChiKey: HOGVQJFBCVTFPV-WJDWOHSUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4Z)-2-(2-fluorophenyl)-4-[(3-methoxy-4-propoxy-phenyl)methylene]oxazol-5-one
(4Z)-2-(2-fluorophenyl)-4-[(3-methoxy-4-propoxyphenyl)methylene]-5-oxazolone
(4Z)-2-(2-fluorophenyl)-4-(3-methoxy-4-propoxy-benzylidene)oxazol-5-one
(4Z)-2-(2-fluorophenyl)-4-[(3-methoxy-4-propoxy-phenyl)methylidene]-1,3-oxazol-5-one
STOCK2S-19623
ZINC02302727

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cysteine protease	0.0141	0.162	0.162
Giardia lamblia	Cathepsin B precursor	0.0168	0.233	0.5
Brugia malayi	Cathepsin L-like precursor	0.0141	0.162	0.162
Onchocerca volvulus	Cathepsin L homolog	0.0141	0.162	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Brugia malayi	Cathepsin L-like precursor	0.0141	0.162	0.162
Onchocerca volvulus		0.0141	0.162	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0141	0.162	0.162
Giardia lamblia	Cathepsin B precursor	0.0168	0.233	0.5
Onchocerca volvulus		0.0141	0.162	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0098	0.0515	0.0515
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0141	0.162	1
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0515	0.0515
Brugia malayi	Cathepsin L-like precursor	0.0141	0.162	0.162
Echinococcus granulosus	cathepsin l1	0.0141	0.162	0.162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0515	0.2212
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0461	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0141	0.162	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0141	0.162	0.1164
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0515	0.0515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0461	1	1
Echinococcus granulosus	cathepsin b	0.0461	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Loa Loa (eye worm)	hypothetical protein	0.0461	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Loa Loa (eye worm)	hypothetical protein	0.0141	0.162	0.1164
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Onchocerca volvulus		0.0141	0.162	1
Toxoplasma gondii	cathepsin B	0.0168	0.233	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0168	0.233	0.233
Echinococcus multilocularis	cathepsin b	0.0461	1	1
Echinococcus granulosus	cathepsin l1	0.0098	0.0515	0.0515
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0141	0.162	0.1164
Onchocerca volvulus	Cathepsin L homolog	0.0141	0.162	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.162	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0461	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0461	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Echinococcus multilocularis	cathepsin b	0.0461	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0461	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0141	0.162	0.162
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0141	0.162	0.162
Loa Loa (eye worm)	fibroinase	0.0141	0.162	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0168	0.233	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Echinococcus multilocularis	cysteine protease	0.0141	0.162	0.162
Giardia lamblia	Cathepsin B precursor	0.0168	0.233	0.5
Brugia malayi	cathepsin L-like precursor	0.0098	0.0515	0.0515
Onchocerca volvulus		0.0141	0.162	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0168	0.233	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.162	0.162
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0141	0.162	0.162
Onchocerca volvulus		0.0141	0.162	1
Loa Loa (eye worm)	cysteine protease	0.0141	0.162	0.1164
Schistosoma mansoni	cathepsin F (C01 family)	0.0141	0.162	0.162
Loa Loa (eye worm)	ctsf protein	0.0141	0.162	0.1164
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0098	0.0515	0.0515
Echinococcus multilocularis	cathepsin L cysteine protease	0.0141	0.162	0.162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.162	0.162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.162	0.162
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0515	0.3182
Echinococcus granulosus	cathepsin b	0.0461	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0141	0.162	0.6951
Loa Loa (eye worm)	cathepsin B	0.0168	0.233	0.1913
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0141	0.162	0.162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0141	0.162	1
Entamoeba histolytica	cysteine proteinase, putative	0.0141	0.162	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0168	0.233	0.233
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Brugia malayi	Cathepsin L-like precursor	0.0141	0.162	0.162
Trypanosoma cruzi	cruzipain precursor, putative	0.0141	0.162	0.162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Onchocerca volvulus	Cathepsin F homolog	0.0141	0.162	1
Brugia malayi	Cathepsin L-like precursor	0.0141	0.162	0.162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Entamoeba histolytica	cysteine protease, putative	0.0141	0.162	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.162	0.6951
Onchocerca volvulus		0.0141	0.162	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0168	0.233	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0141	0.162	0.162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0515	0.2212
Plasmodium vivax	vivapain-2	0.0141	0.162	1
Brugia malayi	Cathepsin L-like precursor	0.0141	0.162	0.162
Onchocerca volvulus		0.0141	0.162	1
Plasmodium vivax	vivapain-2	0.0141	0.162	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0098	0.0515	0.0515
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0141	0.162	0.6951
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.162	0.162
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.162	0.6951
Trypanosoma cruzi	cysteine peptidase, putative	0.0141	0.162	0.162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 897972