Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | LCCL domain-containing protein | 0.0061 | 0.0218 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0255 | 0.5045 | 0.4935 |
Onchocerca volvulus | 0.0099 | 0.1156 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0218 | 0.0741 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0365 | 0.7776 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0455 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0218 | 0.0741 |
Loa Loa (eye worm) | doublecortin family protein | 0.0061 | 0.0218 | 0.0741 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.016 | 0.2665 | 0.2501 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 0.2946 | 0.3609 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0365 | 0.7776 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0171 | 0.2946 | 0.3609 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.3116 | 0.2962 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0171 | 0.2946 | 0.3609 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0163 | 0.2746 | 0.3344 |
Echinococcus multilocularis | ankyrin repeat protein | 0.016 | 0.2665 | 0.3238 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.2946 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.3116 | 0.2962 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.2355 | 0.2184 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0218 | 0.0741 |
Echinococcus multilocularis | geminin | 0.0178 | 0.3116 | 0.3834 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0218 | 0.0741 |
Brugia malayi | Doublecortin family protein | 0.0061 | 0.0218 | 0.0741 |
Echinococcus granulosus | ankyrin repeat protein | 0.016 | 0.2665 | 0.3238 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.2946 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.2355 | 0.2184 |
Schistosoma mansoni | lipoxygenase | 0.0365 | 0.7776 | 0.7726 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0163 | 0.2746 | 0.3344 |
Echinococcus granulosus | geminin | 0.0178 | 0.3116 | 0.3834 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0061 | 0.0218 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.