Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 0.0092 | 0.1156 | 0.1015 | |
Schistosoma mansoni | ryanodine receptor related | 0.0648 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1569 | 0.2045 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0162 | 0.2259 | 0.2455 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0114 | 0.1497 | 0.146 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0234 | 0.3406 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0525 | 0.8038 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.221 | 0.221 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0198 | 0.2841 | 0.2841 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1226 | 0.1226 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0114 | 0.1497 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0242 | 0.354 | 0.543 |
Entamoeba histolytica | protein kinase , putative | 0.0114 | 0.1497 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0114 | 0.1497 | 0.146 |
Giardia lamblia | Aurora kinase | 0.0114 | 0.1497 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.0114 | 0.1497 | 0.146 |
Brugia malayi | cation channel family protein | 0.0277 | 0.4097 | 0.3864 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0075 | 0.0878 | 0.0878 |
Echinococcus granulosus | insulin receptor | 0.0097 | 0.1226 | 0.1107 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0079 | 0.0944 | 0.0944 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0162 | 0.2259 | 0.2455 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0043 | 0.0379 | 0.0379 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0114 | 0.1497 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.1226 | 0.0881 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0114 | 0.1497 | 1 |
Onchocerca volvulus | 0.0043 | 0.0379 | 0.5 | |
Brugia malayi | serine/threonine protein kinase 6 | 0.0114 | 0.1497 | 0.1162 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0944 | 0.0971 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0114 | 0.1497 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.2259 | 0.2259 |
Schistosoma mansoni | tyrosine kinase | 0.03 | 0.4454 | 0.4454 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.03 | 0.4454 | 0.5321 |
Loa Loa (eye worm) | ryanodine receptor | 0.0153 | 0.2122 | 0.2994 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0234 | 0.3406 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0162 | 0.2259 | 0.2259 |
Entamoeba histolytica | protein kinase, putative | 0.0114 | 0.1497 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0114 | 0.1497 | 0.1162 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0409 | 0.6201 | 0.7602 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 0.6201 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.1497 | 0.1921 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.1497 | 0.1921 |
Leishmania major | hypothetical protein, conserved | 0.0159 | 0.2215 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0525 | 0.8038 | 1 |
Schistosoma mansoni | protein kinase | 0.0114 | 0.1497 | 0.1497 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.221 | 0.221 |
Echinococcus granulosus | epidermal growth factor receptor | 0.03 | 0.4454 | 0.5321 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0097 | 0.1226 | 0.1456 |
Entamoeba histolytica | protein kinase, putative | 0.0114 | 0.1497 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.03 | 0.4454 | 0.7 |
Echinococcus multilocularis | insulin receptor | 0.0097 | 0.1226 | 0.1107 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0114 | 0.1497 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0114 | 0.1497 | 0.1162 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.221 | 0.221 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0114 | 0.1497 | 0.146 |
Toxoplasma gondii | aurora kinase | 0.0114 | 0.1497 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0097 | 0.1226 | 0.1107 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.1497 | 0.1921 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.1497 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0162 | 0.2259 | 0.2455 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0409 | 0.6201 | 0.7602 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1226 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.165 | 0.2184 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0114 | 0.1497 | 1 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.2231 | 0.2231 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0097 | 0.1226 | 0.1107 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.1497 | 0.1497 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.03 | 0.4454 | 0.4236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.