Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinesin eg-5 | 0.0193 | 0.1192 | 0.1342 |
Echinococcus multilocularis | thymidylate synthase | 0.0117 | 0.0674 | 0.0646 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0349 | 0.2362 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0063 | 0.0306 | 0.0277 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0236 | 0.1488 | 1 |
Brugia malayi | Doublecortin family protein | 0.0023 | 0.003 | 0.0091 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0117 | 0.0674 | 0.3423 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0287 | 0.1832 | 0.1807 |
Plasmodium falciparum | kinesin-5 | 0.0193 | 0.1192 | 0.797 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0303 | 0.1942 | 0.1918 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.1832 | 0.5513 |
Schistosoma mansoni | lipoxygenase | 0.0063 | 0.0306 | 0.0319 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0287 | 0.1832 | 0.1807 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.003 | 0.0091 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0288 | 0.184 | 0.2091 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1488 | 1 |
Giardia lamblia | Kinesin-5 | 0.0193 | 0.1192 | 0.5 |
Schistosoma mansoni | lozenge | 0.0063 | 0.0309 | 0.0322 |
Loa Loa (eye worm) | calcium channel | 0.0287 | 0.1832 | 0.5513 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.003 | 0.0091 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.0349 | 0.032 |
Brugia malayi | dihydrofolate reductase family protein | 0.0235 | 0.1478 | 0.4448 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0287 | 0.1832 | 0.1807 |
Brugia malayi | hypothetical protein | 0.0023 | 0.003 | 0.0091 |
Echinococcus granulosus | dihydrofolate reductase | 0.0235 | 0.1478 | 0.1452 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.3323 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0193 | 0.1192 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.0349 | 0.032 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0117 | 0.0674 | 0.0744 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.0349 | 0.0369 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0256 | 0.0771 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1488 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0235 | 0.1478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0571 | 0.1718 |
Onchocerca volvulus | 0.0506 | 0.3323 | 1 | |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0193 | 0.1192 | 0.3587 |
Brugia malayi | hypothetical protein | 0.0023 | 0.003 | 0.0091 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0235 | 0.1478 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.008 | 0.0242 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0287 | 0.1832 | 0.2082 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1488 | 1 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0287 | 0.1832 | 0.5513 |
Echinococcus granulosus | ankyrin repeat protein | 0.0288 | 0.184 | 0.1815 |
Brugia malayi | Kinesin motor domain containing protein | 0.0193 | 0.1192 | 0.3587 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0349 | 0.2362 |
Schistosoma mansoni | hypothetical protein | 0.1292 | 0.8685 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0117 | 0.0674 | 0.203 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0303 | 0.1941 | 0.1916 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.3323 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0102 | 0.0571 | 0.1947 |
Brugia malayi | Dihydrofolate reductase | 0.0235 | 0.1478 | 0.4448 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0102 | 0.0571 | 0.1718 |
Loa Loa (eye worm) | runx1 | 0.0063 | 0.0309 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.003 | 0.0091 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0287 | 0.1832 | 0.1807 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.008 | 0.0242 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0287 | 0.1832 | 0.1807 |
Schistosoma mansoni | voltage-gated cation channel | 0.0287 | 0.1832 | 0.2082 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0349 | 0.2362 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1488 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.0349 | 0.076 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.0349 | 0.2347 |
Brugia malayi | thymidylate synthase | 0.0117 | 0.0674 | 0.203 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0235 | 0.1478 | 0.1452 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.0349 | 0.0369 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0236 | 0.1488 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0063 | 0.0306 | 0.0277 |
Echinococcus granulosus | thymidylate synthase | 0.0117 | 0.0674 | 0.0646 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.0256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.047 | 0.1413 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0235 | 0.1478 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0287 | 0.1832 | 0.1807 |
Echinococcus multilocularis | Protein lozenge | 0.0063 | 0.0309 | 0.028 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0235 | 0.1478 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0287 | 0.1832 | 0.1807 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0287 | 0.1832 | 0.1807 |
Mycobacterium ulcerans | thymidylate synthase | 0.0117 | 0.0674 | 0.4563 |
Echinococcus multilocularis | kinesin family 1 | 0.1485 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0235 | 0.1478 | 0.1673 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0287 | 0.1832 | 0.1807 |
Toxoplasma gondii | hypothetical protein | 0.0087 | 0.047 | 0.1058 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0288 | 0.184 | 0.1815 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0193 | 0.1192 | 0.7402 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0287 | 0.1832 | 0.2082 |
Plasmodium vivax | kinesin-5 | 0.0193 | 0.1192 | 0.797 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0102 | 0.0571 | 0.3837 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0102 | 0.0571 | 0.3837 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0102 | 0.0571 | 0.0542 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0235 | 0.1478 | 0.4448 |
Onchocerca volvulus | 0.0117 | 0.0674 | 0.1957 | |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0287 | 0.1832 | 0.1807 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.047 | 0.1413 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0056 | 0.0256 | 0.1723 |
Brugia malayi | hypothetical protein | 0.0506 | 0.3323 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.