TDR Targets

Basic information

Technical information

TDR Targets ID: 902593
Name: N-(2,5-dichlorophenyl)-2-fluorobenzamide
MW: 284.113 | Formula: C13H8Cl2FNO
H donors: 1 H acceptors: 1 LogP: 4.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)NC(=O)c1ccccc1F)Cl
InChi: 1S/C13H8Cl2FNO/c14-8-5-6-10(15)12(7-8)17-13(18)9-3-1-2-4-11(9)16/h1-7H,(H,17,18)
InChiKey: FVDTVVPXXYWDKT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,5-dichlorophenyl)-2-fluoro-benzamide
Oprea1_366482
BAS 00408308
N-(2,5-Dichloro-phenyl)-2-fluoro-benzamide
STK201202
ZINC00139729
Oprea1_455768

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0154	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0154	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0081	0.4347	0.1071
Loa Loa (eye worm)	nuclear hormone receptor	0.0072	0.3669	0.3669
Brugia malayi	nuclear hormone receptor	0.0072	0.3669	0.3669
Brugia malayi	hypothetical protein	0.0072	0.3669	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4347	0.4347
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0154	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Echinococcus granulosus	ecdysone induced protein 78C	0.0154	1	1
Brugia malayi	hypothetical protein	0.0081	0.4347	0.4347
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0154	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0154	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0154	1	1
Schistosoma mansoni	coup transcription factor	0.0154	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0154	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0154	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0154	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	nuclear receptor NHR-88	0.0072	0.3669	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Echinococcus multilocularis	FTZ F1 alpha	0.0154	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0154	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0072	0.3669	0.3669
Brugia malayi	tailless protein	0.0072	0.3669	0.3669
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0081	0.4347	0.1071
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0154	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0154	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0154	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0154	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0154	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0081	0.4347	0.4347
Brugia malayi	Steroid receptor seven-up type 2	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Onchocerca volvulus		0.0154	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0154	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0154	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0154	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0154	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0154	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4347	0.4347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0154	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0081	0.4347	0.4347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	ecdysone receptor	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor E75	0.0072	0.3669	0.3669
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0081	0.4347	0.1071
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0072	0.3669	0.3669
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0072	0.3669	0.3669
Onchocerca volvulus	Protein ultraspiracle homolog	0.0154	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0154	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0072	0.3669	0.3669
Brugia malayi	nuclear receptor RXR	0.0081	0.4347	0.4347
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0154	1	1
Loa Loa (eye worm)	DR-78	0.0072	0.3669	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0154	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor E75	0.0072	0.3669	0.3669
Brugia malayi	nuclear receptor RXR	0.0072	0.3669	0.3669
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0154	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0154	1	1
Brugia malayi	conserved hypotetical protein	0.0072	0.3669	0.3669
Schistosoma mansoni	thyroid hormone receptor	0.0154	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0154	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0154	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0154	1	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0072	0.3669	0.3669
Brugia malayi	nuclear hormone receptor family member odr-7	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0154	1	1
Brugia malayi	nuclear receptor NHR-67	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4347	0.4347
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0154	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0154	1	1
Brugia malayi	nuclear receptor NHR-88	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0154	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0154	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0154	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0154	1	1
Brugia malayi	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0154	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0154	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0081	0.4347	0.1071
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0154	1	1
Brugia malayi	nuclear hormone receptor	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4347	0.4347
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669
Brugia malayi	hypothetical protein	0.0081	0.4347	0.4347
Brugia malayi	steroid hormone receptor	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0154	1	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0081	0.4347	0.4347
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4347	0.4347
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0154	1	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.3669	0.3669

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 902593