Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0141 | 0.1132 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0141 | 0.1132 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0154 | 0.1359 |
Schistosoma mansoni | hypothetical protein | 0.0946 | 0.8676 | 1 |
Plasmodium vivax | kinesin-5 | 0.0141 | 0.1132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0314 | 0.2774 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0314 | 0.2774 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0141 | 0.1132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1052 | 0.9295 |
Brugia malayi | hypothetical protein | 0.0133 | 0.1052 | 0.9295 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0141 | 0.1132 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0314 | 0.2774 |
Trypanosoma brucei | cytochrome P450, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0102 | 0.0905 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1052 | 0.9295 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.1052 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0141 | 0.1132 | 0.1148 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0021 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0141 | 0.1132 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0314 | 0.2774 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0102 | 0.0905 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0154 | 0.1359 |
Leishmania major | cytochrome p450-like protein | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0141 | 0.1132 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.1052 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.1087 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.