Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | carboxylesterase | 0.0369 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.0941 | 0.0268 |
Echinococcus multilocularis | acetylcholinesterase | 0.0369 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0369 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0369 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.0941 | 0.0268 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0.0692 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.0692 | 1 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0091 | 0.0969 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0692 | 0.0692 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0091 | 0.0969 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.0941 | 0.0268 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0.0692 | 0.7353 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0091 | 0.1317 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.0941 | 0.0268 |
Brugia malayi | Heterochromatin protein 1 | 0.0071 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.0941 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Echinococcus multilocularis | acetylcholinesterase | 0.0369 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.0941 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0692 | 0.0692 |
Echinococcus granulosus | acetylcholinesterase | 0.0369 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0692 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0692 | 0.0692 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.0941 | 0.0268 |
Onchocerca volvulus | 0.0062 | 0.0692 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0062 | 0.0692 | 0.0692 |
Echinococcus granulosus | acetylcholinesterase | 0.0369 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0369 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 0.0941 | 0.0941 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.0941 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0692 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0692 | 0.0692 |
Onchocerca volvulus | 0.0062 | 0.0692 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.587 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0.0692 | 0.7353 |
Brugia malayi | Carboxylesterase family protein | 0.0062 | 0.0692 | 0.0692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.15 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | = 3.24 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 114.4 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 122.6 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.