Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.4967 | 1 | 0.5 | |
Toxoplasma gondii | fructose-bisphospatase II | 0.0794 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.4575 | 0.9062 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0794 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4575 | 0.9062 | 0.9062 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0794 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.4967 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.4575 | 0.9062 | 0.5 |
Onchocerca volvulus | 0.4967 | 1 | 0.5 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.4575 | 0.9062 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4967 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.4967 | 1 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.4575 | 0.9062 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0794 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.4575 | 0.9062 | 0.9062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.