Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0148 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0894 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.4732 | 0.4732 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0894 | 0.0894 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0148 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.4732 | 0.4732 |
Onchocerca volvulus | 0.0083 | 0.4732 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0894 | 0.0894 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0894 | 0.0894 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.4732 | 0.4732 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0894 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 1 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.4732 | 0.4732 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0894 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0148 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0148 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0148 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.2175 | 0.2175 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0894 | 0.0894 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0894 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0148 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0894 | 0.0894 |
Brugia malayi | Carboxylesterase family protein | 0.0148 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.4732 | 0.4732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.