Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0075 | 1 | 1 |
Brugia malayi | Plexin repeat family protein | 0.0019 | 0.2045 | 0.7608 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0075 | 1 | 0.5 |
Schistosoma mansoni | plexin | 0.0019 | 0.2045 | 1 |
Onchocerca volvulus | 0.0019 | 0.2045 | 1 | |
Entamoeba histolytica | tyrosin kinase, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | plexin | 0.0011 | 0.0932 | 0.2822 |
Trichomonas vaginalis | AGC family protein kinase | 0.0075 | 1 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0022 | 0.2532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0932 | 0.2147 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2045 | 0.7608 |
Brugia malayi | plexin A | 0.0022 | 0.2532 | 1 |
Echinococcus granulosus | plexin a4 | 0.0022 | 0.2532 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0932 | 0.2822 |
Loa Loa (eye worm) | plexin A | 0.0022 | 0.2532 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0075 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0075 | 1 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0075 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.