Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0041 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0056 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0056 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0041 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.1499 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.1499 | 0.3497 |
Brugia malayi | Cathepsin L-like precursor | 0.0041 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0041 | 0.0274 | 0.1018 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.3497 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0056 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5501 | 0.5375 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0041 | 0.0274 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0056 | 0.086 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0105 | 0.2688 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0105 | 0.2688 | 0.2688 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0056 | 0.086 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0105 | 0.2688 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Plasmodium vivax | vivapain-2 | 0.0056 | 0.086 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0041 | 0.0274 | 0.0274 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.5501 | 0.5501 |
Loa Loa (eye worm) | cathepsin B | 0.0105 | 0.2688 | 0.2482 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0301 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0056 | 0.086 | 0.0603 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0301 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.1499 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0056 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0041 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin F homolog | 0.0056 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0041 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.0105 | 0.2688 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0056 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0056 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0056 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.5501 | 0.5501 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Toxoplasma gondii | cathepsin B | 0.0105 | 0.2688 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0056 | 0.086 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.5501 | 0.5501 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.1499 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0056 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine protease, putative | 0.0056 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0056 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0056 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5501 | 0.5375 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0041 | 0.0274 | 0.1018 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0105 | 0.2688 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0056 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0105 | 0.2688 | 0.2688 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.5501 | 0.5501 |
Echinococcus granulosus | cathepsin l1 | 0.0041 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | cysteine protease | 0.0056 | 0.086 | 0.0603 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0301 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Echinococcus multilocularis | cysteine protease | 0.0056 | 0.086 | 0.086 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0056 | 0.086 | 0.0603 |
Giardia lamblia | Cathepsin B precursor | 0.0105 | 0.2688 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1499 | 0.1499 |
Brugia malayi | Cathepsin L-like precursor | 0.0056 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin b | 0.0301 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0056 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0056 | 0.086 | 0.3201 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1499 | 0.1499 |
Echinococcus multilocularis | cathepsin b | 0.0301 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0056 | 0.086 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0056 | 0.086 | 1 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0105 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Loa Loa (eye worm) | fibroinase | 0.0056 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0056 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0056 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0056 | 0.086 | 0.3201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.