Detailed information for compound 906763

Basic information

Technical information
  • TDR Targets ID: 906763
  • Name: (4Z)-4-[(3,4-dichlorophenyl)methylidene]-2-(4 -methylphenyl)-1,3-oxazol-5-one
  • MW: 332.181 | Formula: C17H11Cl2NO2
  • H donors: 0 H acceptors: 1 LogP: 5.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C1=NC(=Cc2ccc(c(c2)Cl)Cl)C(=O)O1
  • InChi: 1S/C17H11Cl2NO2/c1-10-2-5-12(6-3-10)16-20-15(17(21)22-16)9-11-4-7-13(18)14(19)8-11/h2-9H,1H3/b15-9-
  • InChiKey: GIALTJFRWWDURV-DHDCSXOGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z)-4-[(3,4-dichlorophenyl)methylene]-2-(4-methylphenyl)oxazol-5-one
  • (4Z)-4-[(3,4-dichlorophenyl)methylene]-2-(4-methylphenyl)-5-oxazolone
  • (4Z)-4-(3,4-dichlorobenzylidene)-2-(4-methylphenyl)oxazol-5-one
  • ZINC04644577

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Onchocerca volvulus 0.0025 0.0437 0.9137
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0437 0.1166
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0145 0.0388
Brugia malayi neuropeptide F receptor 0.0025 0.0437 0.1166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0437 0.0437
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0437 0.0437
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Onchocerca volvulus 0.0026 0.0455 1
Echinococcus multilocularis neuropeptide receptor 0.0355 1 1
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0437 0.0437
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0437 0.1166
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0145 0.0145
Schistosoma mansoni neuropeptide receptor 0.0355 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni amine GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis sex peptide receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0437 0.0437
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.074 0.1975
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0437 0.0437
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0455 0.3201
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0455 0.086
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0437 0.0437
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0145 0.0145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0437 0.1166
Toxoplasma gondii cathepsin B 0.0049 0.1113 1
Onchocerca volvulus 0.0025 0.0437 0.9137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Plasmodium vivax vivapain-2 0.0026 0.0455 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0437 0.0437
Schistosoma mansoni biogenic amine receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis cysteine protease 0.0026 0.0455 0.0455
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0455 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Loa Loa (eye worm) fibroinase 0.0026 0.0455 0.1215
Onchocerca volvulus 0.0026 0.0455 1
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0437 0.0437
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0437 0.0437
Schistosoma mansoni neuropeptide receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0437 0.1166
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.074 0.074
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0437 0.0437
Schistosoma mansoni biogenic amine receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Schistosoma mansoni adenoreceptor 0.0025 0.0437 0.0437
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0455 0.0455
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0437 0.0437
Brugia malayi Dopamine receptor protein 1 0.0025 0.0437 0.1166
Schistosoma mansoni opsin-like receptor 0.0025 0.0437 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0455 0.0455
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0437 0.0437
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0437 0.0437
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0437 0.1166
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0437 0.1166
Onchocerca volvulus 0.0025 0.0437 0.9137
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0031 0.0602 0.1608
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0139 0.3747 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0455 0.0455
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0455 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis somatostatin receptor 0.0025 0.0437 0.0437
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0455 0.086
Echinococcus granulosus g protein coupled receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0437 0.1166
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0437 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0437 0.0437
Echinococcus granulosus fmrfamide receptor 0.0025 0.0437 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0437 0.0437
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0437 0.0437
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0244 0.3182
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis serotonin receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis cathepsin b 0.0139 0.3747 0.3747
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Onchocerca volvulus 0.0025 0.0437 0.9137
Echinococcus granulosus cathepsin b 0.0139 0.3747 0.3747
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0437 0.0437
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0437 0.0437
Brugia malayi larval opioid receptor 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis cathepsin b 0.0139 0.3747 0.3747
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0437 0.1166
Loa Loa (eye worm) cathepsin B 0.0049 0.1113 0.2971
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.0244 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus granulosus neuropeptide receptor 0.0025 0.0437 0.0437
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0437 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus granulosus cathepsin L 0.0015 0.0145 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0437 0.0437
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.3747 0.3747
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0437 0.1166
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.074 0.1975
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0437 0.9137
Echinococcus granulosus g protein coupled receptor 0.0025 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.0026 0.0455 0.1215
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0437 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0455 0.086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.0019 0.0244 0.0651
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0455 0.1215
Brugia malayi neuropeptide F receptor 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0244 0.1018
Schistosoma mansoni amine GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Onchocerca volvulus 0.0025 0.0437 0.9137
Giardia lamblia Cathepsin B precursor 0.0049 0.1113 0.5
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Onchocerca volvulus 0.0025 0.0437 0.9137
Plasmodium vivax vivapain-2 0.0026 0.0455 1
Brugia malayi Melatonin receptor type 1A 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0019 0.0244 0.0651
Brugia malayi cathepsin L-like precursor 0.0019 0.0244 0.0651
Echinococcus granulosus somatostatin receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0026 0.0455 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0455 1
Schistosoma mansoni hypothetical protein 0.0025 0.0437 0.0437
Brugia malayi GnHR receptor homolog 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0139 0.3747 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0455 0.1215
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0437 0.0437
Brugia malayi ORL1-like opioid receptor 0.0025 0.0437 0.1166
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0455 0.086
Onchocerca volvulus 0.0025 0.0437 0.9137
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0049 0.1113 0.2688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) cysteine protease 0.0026 0.0455 0.1215
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0437 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Schistosoma mansoni neuropeptide receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0026 0.0455 1
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0455 0.086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0455 0.0455
Brugia malayi G-protein coupled receptor 0.0025 0.0437 0.1166
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0455 0.0455
Brugia malayi Serotonin receptor 0.0025 0.0437 0.1166
Brugia malayi cathepsin B-like cysteine proteinase 0.0139 0.3747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0019 0.0244 0.0651
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Giardia lamblia Cathepsin B precursor 0.0049 0.1113 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Schistosoma mansoni myosin xvIII 0.0025 0.0437 0.0437
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0437 0.1166
Brugia malayi sulfakinin receptor protein 0.0025 0.0437 0.1166
Echinococcus multilocularis serotonin receptor 0.0025 0.0437 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0437 0.1166
Loa Loa (eye worm) ctsf protein 0.0026 0.0455 0.1215
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0836 0.0836
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0455 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0026 0.0455 0.1215
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0437 0.0437
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0049 0.1113 0.1113
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0455 1
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.0145 0.0145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis G protein coupled receptor 139 0.0355 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.3747 0.3747
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0437 0.0437
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Onchocerca volvulus 0.0025 0.0437 0.9137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trypanosoma brucei cysteine peptidase C (CPC) 0.0049 0.1113 1
Giardia lamblia Cathepsin B precursor 0.0049 0.1113 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0437 0.1166
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0437 0.0437
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0455 0.1215
Schistosoma mansoni amine GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.0026 0.0455 0.1215
Schistosoma mansoni biogenic amine receptor 0.0025 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.0026 0.0455 0.1215
Brugia malayi AKH receptor 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi Cathepsin L-like precursor 0.0026 0.0455 0.1215
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0455 0.1215
Brugia malayi Serotonin receptor 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0437 0.0437
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni histamine h1 receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Onchocerca volvulus 0.0026 0.0455 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis cathepsin L 0.0015 0.0145 0.0145
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0437 0.0437
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0671 0.5434
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0437 0.0437
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0437 0.0437
Brugia malayi G-protein coupled receptor 0.0025 0.0437 0.1166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0437 0.1166
Echinococcus granulosus allatostatin A receptor 0.0025 0.0437 0.0437
Schistosoma mansoni hypothetical protein 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.074 0.074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0455 0.3201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0437 0.0437
Brugia malayi G protein-coupled receptor 0.0025 0.0437 0.1166
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0026 0.0455 1
Schistosoma mansoni neuropeptide receptor 0.0025 0.0437 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Entamoeba histolytica cysteine protease, putative 0.0026 0.0455 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0671 0.5434
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0437 0.1166
Schistosoma mansoni hypothetical protein 0.0025 0.0437 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0244 0.1018
Schistosoma mansoni opsin-like receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0437 0.0437
Echinococcus granulosus sex peptide receptor 0.0025 0.0437 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0049 0.1113 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0437 0.0437
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0437 0.0437
Echinococcus granulosus cathepsin b 0.0139 0.3747 0.3747
Echinococcus granulosus hypothetical protein 0.0025 0.0437 0.0437
Schistosoma mansoni opsin-like receptor 0.0025 0.0437 0.0437
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0145 0.0388
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis cysteine protease 0.0026 0.0455 0.0455
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0437 0.0437
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0437 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni hypothetical protein 0.0025 0.0437 0.0437
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi hypothetical protein 0.0025 0.0437 0.1166
Echinococcus granulosus cathepsin l1 0.0026 0.0455 0.0455
Brugia malayi RE15519p 0.0025 0.0437 0.1166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0437 0.0437
Brugia malayi putative neuropeptide receptor 0.0025 0.0437 0.1166
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0455 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0244 0.0244
Brugia malayi Dopamine receptor protein 2 0.0025 0.0437 0.1166
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0437 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0437 0.0437
Schistosoma mansoni amine GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0139 0.3747 0.3747
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0437 0.9137
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0437 0.1166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Onchocerca volvulus 0.0026 0.0455 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0145 0.0145
Echinococcus granulosus orexin receptor type 2 0.0025 0.0437 0.0437
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0437 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0019 0.0244 0.0651
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0437 0.0437
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0437 0.0437
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0437 0.0437
Echinococcus granulosus serotonin receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0437 0.0437
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0437 0.0437
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0437 0.0437
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0437 0.0437
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0437 0.0437
Brugia malayi Cathepsin L-like precursor 0.0026 0.0455 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0455 0.3201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Echinococcus granulosus cysteine protease 0.0015 0.0145 0.0145
Echinococcus granulosus cathepsin l1 0.0019 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Brugia malayi Cathepsin L-like precursor 0.0019 0.0244 0.0651
Brugia malayi Dopamine receptor 0.0025 0.0437 0.1166
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0049 0.1113 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0437 0.0437
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0437 0.0437
Echinococcus granulosus g protein coupled receptor 0.0025 0.0437 0.0437
Onchocerca volvulus 0.0025 0.0437 0.9137
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0437 0.0437
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni amine GPCR 0.0025 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0437 0.1166
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0437 0.0437
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0836 0.0836
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0455 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.3747 0.3747
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0019 0.0244 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0455 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0455 0.3201
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0455 0.0455

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.