Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.086 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0057 | 0.2688 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0022 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0057 | 0.2688 | 0.2688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.003 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.003 | 0.086 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.003 | 0.086 | 0.0603 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0163 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0163 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2688 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.003 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin L homolog | 0.003 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2688 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.003 | 0.086 | 0.086 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0274 | 0.0274 |
Echinococcus granulosus | cathepsin l1 | 0.003 | 0.086 | 0.086 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.003 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0022 | 0.0274 | 0.0274 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0163 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0274 | 0.1018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.003 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.003 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.003 | 0.086 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0057 | 0.2688 | 0.2688 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.003 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.003 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin F homolog | 0.003 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine protease, putative | 0.003 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0274 | 0.1018 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.003 | 0.086 | 0.086 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0057 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Plasmodium vivax | vivapain-2 | 0.003 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.003 | 0.086 | 1 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0274 | 0.0274 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0057 | 0.2688 | 1 |
Loa Loa (eye worm) | fibroinase | 0.003 | 0.086 | 0.0603 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.003 | 0.086 | 0.086 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.0022 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.0057 | 0.2688 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0057 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.003 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.003 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.003 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.003 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0022 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | ctsf protein | 0.003 | 0.086 | 0.0603 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.003 | 0.086 | 0.086 |
Loa Loa (eye worm) | cysteine protease | 0.003 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.003 | 0.086 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0022 | 0.0274 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.0163 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0057 | 0.2688 | 0.2482 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.003 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.003 | 0.086 | 0.3201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.