Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor 2 | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0034 | 0.084 | 0.084 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.3053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0079 | 0.42 | 0.42 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.084 | 0.084 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.084 | 0.084 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0022 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0057 | 0.2561 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.009 | 0.5001 | 0.5001 |
Echinococcus granulosus | glutamate receptor 2 | 0.0034 | 0.084 | 0.084 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.084 | 0.084 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0057 | 0.2561 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0157 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0034 | 0.084 | 0.084 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0078 | 0.4161 | 0.4161 |
Echinococcus granulosus | nmda type glutamate receptor | 0.009 | 0.5001 | 0.5001 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0063 | 0.3053 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0112 | 0.664 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0057 | 0.2561 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.084 | 0.084 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.3053 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.3053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.3053 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.2646 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0078 | 0.4161 | 0.4161 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0057 | 0.2561 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0034 | 0.084 | 0.084 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.3053 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0034 | 0.084 | 0.084 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0057 | 0.2561 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0034 | 0.084 | 0.084 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.3053 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0057 | 0.2561 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.3053 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0022 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.