TDR Targets

Basic information

Technical information

TDR Targets ID: 908743
Name: N-(3-methylphenyl)-6-nitro-2,1,3-benzoxadiazo l-7-amine
MW: 270.244 | Formula: C13H10N4O3
H donors: 1 H acceptors: 4 LogP: 3.46 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)Nc1c(ccc2c1non2)[N+](=O)[O-]
InChi: 1S/C13H10N4O3/c1-8-3-2-4-9(7-8)14-13-11(17(18)19)6-5-10-12(13)16-20-15-10/h2-7,14H,1H3
InChiKey: KJUDSMNPOOLXPW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3-methylphenyl)-(5-nitrobenzofurazan-4-yl)amine
Oprea1_368655
ZINC03904277

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AKH receptor	0.0063	0.3032	1
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.3032	0.59
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0063	0.3032	0.5
Brugia malayi	ORL1-like opioid receptor	0.0063	0.3032	1
Brugia malayi	Dopamine receptor protein 2	0.0063	0.3032	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0063	0.3032	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0256	0.0256
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.3032	1
Schistosoma mansoni	biogenic amine receptor	0.0063	0.3032	0.59
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Echinococcus granulosus	somatostatin receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.3032	0.4813
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0256	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	serotonin receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Brugia malayi	putative neuropeptide receptor NPR1	0.0063	0.3032	1
Schistosoma mansoni	opsin-like receptor	0.0063	0.3032	0.59
Brugia malayi	Serotonin receptor	0.0063	0.3032	1
Schistosoma mansoni	neuropeptide receptor	0.0063	0.3032	0.59
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	TYRA-2 protein	0.0063	0.3032	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Schistosoma mansoni	glutamate receptor NMDA	0.009	0.4962	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0063	0.3032	0.59
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	hypothetical protein	0.0063	0.3032	0.4813
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.3032	0.4813
Brugia malayi	larval opioid receptor	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0256	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0063	0.3032	0.4813
Brugia malayi	neuropeptide F receptor	0.0063	0.3032	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0256	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.3032	0.59
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0256	0.0256
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0063	0.3032	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0063	0.3032	0.59
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	neuropeptide receptor	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.3032	0.59
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Brugia malayi	sulfakinin receptor protein	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0063	0.3032	0.59
Brugia malayi	GnHR receptor homolog	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	neuropeptide receptor A26	0.0063	0.3032	0.4813
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.3032	0.4813
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.3032	1
Schistosoma mansoni	biogenic amine receptor	0.0063	0.3032	0.59
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Brugia malayi	G protein-coupled receptor	0.0063	0.3032	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Schistosoma mansoni	histamine h1 receptor	0.0063	0.3032	0.59
Loa Loa (eye worm)	melatonin receptor type 1A	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Brugia malayi	RE15519p	0.0063	0.3032	1
Echinococcus granulosus	neuropeptide Y receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.3032	0.4813
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0019	0	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0063	0.3032	0.59
Brugia malayi	Dopamine receptor protein 1	0.0063	0.3032	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0063	0.3032	0.4813
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	nmda type glutamate receptor	0.0105	0.6026	1
Echinococcus granulosus	nmda type glutamate receptor	0.0083	0.4444	0.7258
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0063	0.3032	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0063	0.3032	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0063	0.3032	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0256	0.5
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus multilocularis	serotonin receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0256	0.5
Onchocerca volvulus		0.0063	0.3032	0.5
Brugia malayi	G-protein coupled receptor	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0063	0.3032	0.59
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptides capa receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	sex peptide receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0063	0.3032	0.59
Schistosoma mansoni	neuropeptide receptor	0.0063	0.3032	0.59
Schistosoma mansoni	biogenic amine receptor	0.0063	0.3032	0.59
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0256	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0063	0.3032	0.59
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0063	0.3032	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0063	0.3032	0.59
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0063	0.3032	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Echinococcus granulosus	g protein coupled receptor	0.0063	0.3032	0.4813
Brugia malayi	neuropeptide F receptor	0.0063	0.3032	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	neuropeptide receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.3032	0.59
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0256	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0063	0.3032	0.4813
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.3032	0.4813
Echinococcus granulosus	fmrfamide receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptide receptor A26	0.0063	0.3032	0.4813
Echinococcus multilocularis	allatostatin A receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	g protein coupled receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	neuropeptide receptor	0.0063	0.3032	0.59
Echinococcus multilocularis	neuropeptide s receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0063	0.3032	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0063	0.3032	0.59
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0256	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Brugia malayi	Melatonin receptor type 1A	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	neuropeptide s receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0063	0.3032	0.59
Echinococcus granulosus	G protein coupled receptor 139	0.0063	0.3032	0.4813
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.3032	0.4813
Echinococcus multilocularis	fmrfamide receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	biogenic amine 5HT receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	amine GPCR	0.0063	0.3032	0.59
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Brugia malayi	Serotonin receptor	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Brugia malayi	putative neuropeptide receptor	0.0063	0.3032	1
Echinococcus granulosus	allatostatin A receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	glutamate receptor NMDA	0.0079	0.4178	0.6797
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	glutamate receptor NMDA	0.0079	0.4178	0.6797
Onchocerca volvulus		0.0063	0.3032	0.5
Chlamydia trachomatis	glutamine binding protein	0.0019	0	0.5
Schistosoma mansoni	hypothetical protein	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	adenoreceptor	0.0063	0.3032	0.59
Schistosoma mansoni	opsin-like receptor	0.0063	0.3032	0.59
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0063	0.3032	1
Schistosoma mansoni	amine GPCR	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0063	0.3032	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0063	0.3032	0.59
Echinococcus granulosus	g-protein coupled receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	hypothetical protein	0.0063	0.3032	0.59
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0063	0.3032	0.4813
Brugia malayi	follicle stimulating hormone receptor	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	serotonin receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	hypothetical protein	0.0063	0.3032	0.59
Echinococcus multilocularis	neuropeptide receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0063	0.3032	0.4813
Schistosoma mansoni	myosin xvIII	0.0063	0.3032	0.59
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Schistosoma mansoni	amine GPCR	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	nmda type glutamate receptor	0.0083	0.4444	0.7258
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0063	0.3032	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0256	1
Echinococcus granulosus	neuropeptide receptor	0.0063	0.3032	0.4813
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0256	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0063	0.3032	0.59
Echinococcus granulosus	dro:myosuppressin receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	orexin receptor type 2	0.0063	0.3032	0.4813
Onchocerca volvulus		0.0063	0.3032	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0063	0.3032	0.59
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0063	0.3032	0.4813
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptide Y receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0063	0.3032	0.4813
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0256	0.5
Onchocerca volvulus		0.0063	0.3032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0063	0.3032	0.5
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Schistosoma mansoni	amine GPCR	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Onchocerca volvulus		0.0063	0.3032	0.5
Echinococcus granulosus	g protein coupled receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.3032	0.4813
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0256	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.3032	0.59
Schistosoma mansoni	hypothetical protein	0.0063	0.3032	0.59
Onchocerca volvulus		0.0063	0.3032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	somatostatin receptor	0.0063	0.3032	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0063	0.3032	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0063	0.3032	0.4813
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0519	0.0456
Echinococcus multilocularis	g protein coupled receptor	0.0063	0.3032	0.4813
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0063	0.3032	0.4813
Brugia malayi	G-protein coupled receptor	0.0063	0.3032	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0063	0.3032	0.4813
Schistosoma mansoni	amine GPCR	0.0063	0.3032	0.59
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Brugia malayi	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	g-protein coupled receptor	0.0063	0.3032	0.4813
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0162	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0063	0.3032	0.4813
Echinococcus granulosus	orexin receptor type 2	0.0063	0.3032	0.4813
Echinococcus granulosus	nmda type glutamate receptor	0.0105	0.6026	1
Echinococcus granulosus	neuropeptides capa receptor	0.0063	0.3032	0.4813
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Echinococcus multilocularis	G protein coupled receptor 139	0.0063	0.3032	0.4813
Schistosoma mansoni	opsin-like receptor	0.0063	0.3032	0.59
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Toxoplasma gondii	exonuclease III APE	0.0023	0.0256	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0063	0.3032	0.4813
Brugia malayi	Dopamine receptor	0.0063	0.3032	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0063	0.3032	0.59
Schistosoma mansoni	neuropeptide F-like receptor	0.0063	0.3032	0.59
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3032	1
Echinococcus multilocularis	sex peptide receptor	0.0063	0.3032	0.4813
Echinococcus granulosus	tm gpcr rhodopsin	0.0063	0.3032	0.4813
Loa Loa (eye worm)	G-protein coupled receptor	0.0063	0.3032	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0063	0.3032	0.4813

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0024 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.4716 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1869585
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 908743