Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0168 | 0.1086 | 1 |
Brugia malayi | Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein | 0.0321 | 0.2664 | 0.8683 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1086 | 1 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0321 | 0.2664 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.1033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.3068 | 0.3068 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0345 | 0.291 | 1 |
Leishmania major | phospholipase A1, putative | 0.0321 | 0.2664 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.036 | 0.3068 | 0.0551 |
Trypanosoma cruzi | phospholipase A1, putative | 0.0321 | 0.2664 | 1 |
Giardia lamblia | DNA repair protein RAD52 | 0.0345 | 0.291 | 0.5 |
Trypanosoma brucei | phospholipase A1, putative | 0.0321 | 0.2664 | 0.5 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1086 | 1 |
Brugia malayi | Phospholipase A2 family protein | 0.036 | 0.3068 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1086 | 1 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.0321 | 0.2664 | 0.2664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.