Detailed information for compound 909931

Basic information

Technical information
  • TDR Targets ID: 909931
  • Name: 2-bromo-N-[4-(ethyl-phenylsulfamoyl)phenyl]be nzamide
  • MW: 459.356 | Formula: C21H19BrN2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)NC(=O)c1ccccc1Br)c1ccccc1
  • InChi: 1S/C21H19BrN2O3S/c1-2-24(17-8-4-3-5-9-17)28(26,27)18-14-12-16(13-15-18)23-21(25)19-10-6-7-11-20(19)22/h3-15H,2H2,1H3,(H,23,25)
  • InChiKey: IVBNDGSXXCLZKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-bromo-N-[4-(ethyl-phenyl-sulfamoyl)phenyl]benzamide
  • ZINC00676980
  • STK125997
  • ARONIS005224
  • AN-329/41921750

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0072 0.4849 1
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.603 0.2292
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0094 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0077 0.603 1
Onchocerca volvulus 0.0072 0.4849 0.5
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Toxoplasma gondii AGC kinase 0.0077 0.603 0.2292
Onchocerca volvulus 0.0072 0.4849 0.5
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0082 0.7335 0.4826
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0094 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Echinococcus multilocularis aldo keto reductase 0.0072 0.4849 0.4849
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Echinococcus granulosus hypothetical protein 0.0072 0.4849 0.4849
Echinococcus granulosus aldo keto reductase 0.0072 0.4849 0.4849
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0094 1 1
Echinococcus granulosus aldo keto reductase 0.0072 0.4849 0.4849
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0077 0.603 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.603 0.2292
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0094 1 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0094 1 1
Echinococcus granulosus aldo keto reductase 0.0072 0.4849 0.4849
Onchocerca volvulus 0.0072 0.4849 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0082 0.7335 0.7335
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0077 0.603 1
Onchocerca volvulus 0.0072 0.4849 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Leishmania major protein kinase A catalytic subunit isoform 2 0.0077 0.603 1
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.603 0.2292
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.603 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.603 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0072 0.4849 0.5
Onchocerca volvulus 0.0072 0.4849 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Loa Loa (eye worm) AGC/PKA protein kinase 0.0077 0.603 0.2292
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0076 0.5825 0.5825
Loa Loa (eye worm) AGC/PKA protein kinase 0.0077 0.603 0.2292
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Leishmania major protein kinase A catalytic subunit isoform 1 0.0077 0.603 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Echinococcus multilocularis aldo keto reductase 0.0072 0.4849 0.4849
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0077 0.603 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Toxoplasma gondii AGC kinase 0.0077 0.603 0.2292
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.603 0.2292
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0094 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0077 0.603 1
Trichomonas vaginalis AGC family protein kinase 0.0077 0.603 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Echinococcus multilocularis aldo keto reductase 0.0072 0.4849 0.4849
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0077 0.603 1
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Mycobacterium ulcerans oxidoreductase 0.0072 0.4849 0.5
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0077 0.603 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0077 0.603 0.2292
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0077 0.603 1
Giardia lamblia Kinase, AGC PKA 0.0077 0.603 0.2292
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0082 0.7335 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0077 0.603 0.603
Onchocerca volvulus 0.0072 0.4849 0.5
Leishmania major protein kinase A catalytic subunit 0.0077 0.603 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0076 0.5825 0.5825
Echinococcus multilocularis aldo keto reductase 0.0072 0.4849 0.4849
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0072 0.4849 0.4849
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0077 0.603 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0082 0.7335 0.7335
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0072 0.4849 0.4849
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0077 0.603 0.4748

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.