Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0173 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0173 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0064 | 0.0502 | 0.0502 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0064 | 0.0502 | 0.0502 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0064 | 0.0502 | 0.0502 |
Giardia lamblia | Kinase, CMGC CLK | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0173 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0173 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0059 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0173 | 1 | 1 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0064 | 0.0502 | 0.0502 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0173 | 1 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0064 | 0.0502 | 0.0502 |
Leishmania major | 0.0173 | 1 | 1 | |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0173 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.