Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1227 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0245 | 0.0245 |
Brugia malayi | hypothetical protein | 0.01 | 0.0245 | 0.0245 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1227 | 1 | 1 |
Echinococcus multilocularis | presenilin | 0.0206 | 0.116 | 0.0938 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0206 | 0.116 | 0.0938 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0206 | 0.116 | 1 |
Brugia malayi | hypothetical protein | 0.01 | 0.0245 | 0.0245 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0193 | 0.105 | 0.105 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0193 | 0.105 | 0.0825 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0478 | 0.3515 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0478 | 0.3515 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0193 | 0.105 | 0.105 |
Brugia malayi | Presenilin family protein | 0.0206 | 0.116 | 0.116 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0206 | 0.116 | 1 |
Echinococcus granulosus | presenilin | 0.0206 | 0.116 | 0.0938 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0206 | 0.116 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0206 | 0.116 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0206 | 0.116 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1227 | 1 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0193 | 0.105 | 0.0825 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1227 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0478 | 0.3515 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.